Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | ALKBH3 | Q96Q83 | 2/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17501694 | 0.73 | TRPC5 (0.68) | KDM4EUSP2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL17501680 | 0.70 | HSD17B10 (0.49) | MAPTTP53KDM4EHPGDALDH1A1 | |
| SCHEMBL17517369 | 0.66 | TRPC5 (0.67) | MAPTKDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL17501656 | 0.65 | TRPC5 (0.63) | MAPTKDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL4211573 | 0.63 | CA12 (0.51) | TP53KDM4EGAAHPGDALDH1A1 | |
| SCHEMBL20752037 | 0.62 | TRPC5 (0.53) | MAPTTP53KDM4EGAAHPGD | |
| SCHEMBL6508709 | 0.61 | GAA (0.42) | MAPTTP53KDM4EGAAHPGD | |
| SCHEMBL4211671 | 0.60 | CA12 (0.54) | MAPTKDM4EGAAHPGDUSP2 | |
| SCHEMBL17517371 | 0.60 | TRPC5 (0.61) | TP53TSHRTRPC5LMNAKMT2A | |
| SCHEMBL17501699 | 0.60 | TRPC5 (0.67) | MAPTTP53KDM4EHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3180318-A1 | QUINAZOLINE-2,4(1H,3H)-DIONE DERIVATIVES AS TRCP5 MODULATORS FOR THE TREATMENT OF NEUROPSYCHIATRY DISORDERS | Hydra Biosciences, Inc. (US) | 2017-06-21 | — | — | EP | disclosed |
| WO-2016023826-A1 | QUINAZOLINE-2,4(1H,3H)-DIONE DERIVATIVES AS TRCP5 MODULATORS FOR THE TREATMENT OF NEUROPSYCHIATRY DISORDERS | HYDRA BIOSCIENCES, INC. (US) | 2016-02-18 | — | — | WO | disclosed |