TRPC5 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL5132022	0.51	12/20
SCHEMBL682184	0.34	10/20
SCHEMBL4813164	0.74	9/20
SCHEMBL1302848	0.46	8/20
SCHEMBL1009317	0.54	7/20
SCHEMBL5228756	0.53	7/20
SCHEMBL877544	0.45	7/20
SCHEMBL4980958	0.48	6/20
SCHEMBL3236885	0.52	5/20
SCHEMBL5091188	0.45	5/20
SCHEMBL1302632	0.41	5/20
SCHEMBL4151770	0.38	5/20
SCHEMBL1231979	0.37	5/20
Galangin (SCHEMBL117225)	1.00	4/20
Morin (SCHEMBL5248628)	0.89	4/20
Morin (SCHEMBL2118429)	0.75	4/20
Kaempferol (SCHEMBL731179)	0.68	4/20
Quercetin (SCHEMBL444562)	0.67	4/20
SCHEMBL1160941	0.65	4/20
SCHEMBL1879631	0.51	4/20

Clinical trials — most relevant to TRPC5 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Mechanisms of Capsaicin Treatment in Idiopathic Rhinitis Patients and Controls	PHASE4	COMPLETED
Switching From Restasis to TRYPTYR	PHASE4	NOT_YET_RECRUITING
TRPV Expression in Subjects With Sensitive Skin	PHASE4	UNKNOWN
Role of Intralipid in Management of Organophosphorus Poisoning	PHASE2/PHASE3	WITHDRAWN
The Re-Prosper HF Study	PHASE2/PHASE3	COMPLETED
Sodium Citrate in Smell Retraining for People With Post-COVID-19 Olfactory Dysfunction	PHASE2	ACTIVE_NOT_RECRUITING
Safety and Efficacy of MEM 1003 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease	PHASE2	COMPLETED
TRPM8 Activators for Peripheral Neuropathy	PHASE2	ACTIVE_NOT_RECRUITING
Calcium Channel Blockade in Primary Aldosteronism	PHASE2	COMPLETED
Study Designed to Evaluate Safety and Efficacy of 1% Topical Formulation of KM-001 on Type 1 Punctate Palmoplantar Keratoderma or Pachyonychia Congenita Diseases	PHASE1	COMPLETED
A Study of CAR-GPRC5D in Patients With Relapsed/Refractory Multiple Myeloma or Plasma Cell Leukemia	PHASE1	RECRUITING
Assessment of KM-001 - Safety, Tolerability, and Efficacy in Patients With PPPK1 or PC	PHASE1	COMPLETED
Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8	EARLY_PHASE1	COMPLETED
Mechanisms of Human Heat Perception - Involvement of TRPA1, TRPV1 and TRPM3	EARLY_PHASE1	COMPLETED
Factors Affecting Salt Intake in Young Adults	nan	UNKNOWN
Neurogenic Mechanisms in Burning Mouth Syndrome	nan	COMPLETED
Relationship Between Polymorphisms of TRPV1 and KCC2 Gene in Children With Febrile Seizures	nan	COMPLETED
Detection of Cav1 Calcium Channels in Inflammatory Cells of Asthmatic Children	nan	COMPLETED
Identification of TRP Channels as New Potential Therapeutic Targets in Primary and Secondary Raynaud's Phenomenon.	nan	COMPLETED
The Natural History of TRPV4 Neuropathy	nan	RECRUITING
Mediators in Nasal Hyperreactivity in Allergic Rhinitis and Chronic Rhinosinusitis	nan	UNKNOWN
Effects of Photobiomodulation on the Innate Immune System of Neonates and Infants With Bronchiolitis	nan	UNKNOWN
Qutenza 8% Capsaicin Topical System for the Treatment of Neuropathic Axial Lower Back Pain and Lumbosacral Radiculopathy	nan	ENROLLING_BY_INVITATION
An Investigation Into the Mechanism of Inhalation Cough Challenge	nan	COMPLETED
Visual Activity Evoked by Infrared in Humans After Dark Adaptation	nan	COMPLETED
Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin	nan	ENROLLING_BY_INVITATION
Affective Touch, Hedonia and Suicidal Behavior	nan	COMPLETED
Dissecting the Heterogeneity of Oral Cancer Pain	nan	UNKNOWN
Trigeminal Endonasal Perception: A Predictor for Septoplasty Outcome	nan	COMPLETED
A Mechanistic Evaluation of the Nociceptive Desensitizing Properties of Topical Capsaicin	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a TRPC5 binder may also engage these)

Protein	Name	Similarity
Q9MYV9	—	1.000	Q9MYV9 →
O62852	—	1.000	O62852 →
Q9QX29	—	1.000	Q9QX29 →
P79100	—	1.000	P79100 →
Q9QUQ5	—	1.000	Q9QUQ5 →
O35119	—	0.999	O35119 →
Q61056	—	0.999	Q61056 →
TRPC4	Short transient receptor potential channel 4	0.998	landscape →
TRPC1	Short transient receptor potential channel 1	0.998	landscape →
P34586	—	0.997	P34586 →
P19334	—	0.997	P19334 →
P48994	—	0.996	P48994 →
Q704Y3	—	0.994	Q704Y3 →
TRPV1	Transient receptor potential cation channel subfamily V member 1	0.994	landscape →
Q9QX01	—	0.993	Q9QX01 →
O18784	—	0.992	O18784 →
Q9TUN9	—	0.991	Q9TUN9 →
Q6RX08	—	0.990	Q6RX08 →
Q9ERZ8	—	0.990	Q9ERZ8 →
Q6R5A3	—	0.990	Q6R5A3 →
A0A1D5PXA5	—	0.990	A0A1D5PXA5 →
Q9XSM3	—	0.990	Q9XSM3 →
Q5RCN4	—	0.990	Q5RCN4 →
Q9R186	—	0.990	Q9R186 →
Q9VJJ7	—	0.990	Q9VJJ7 →
Q9EPK8	—	0.990	Q9EPK8 →
O60353	—	0.989	O60353 →
P69744	—	0.989	P69744 →
Q7TQ69	—	0.988	Q7TQ69 →
Q8K424	—	0.988	Q8K424 →