Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 9/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12528284 | 1.00 | MCHR1 (0.42) | MCHR1KDM4ELMNAACACBTMEM97 | |
| SCHEMBL12547560 | 1.00 | MCHR1 (0.42) | MCHR1KDM4ELMNAACACBTMEM97 | |
| SCHEMBL12528340 | 0.89 | KDM4E (0.53) | MCHR1KDM4ELMNAHRH3KDM1A | |
| SCHEMBL1750468 | 0.89 | KDM4E (0.53) | MCHR1KDM4ELMNAHRH3KDM1A | |
| SCHEMBL1750535 | 0.89 | KDM4E (0.51) | MCHR1KDM4ELMNAACACBTMEM97 | |
| SCHEMBL2636321 | 0.89 | MCHR1 (0.41) | MCHR1KDM4EACACBHRH3ALDH1A1 | |
| SCHEMBL1749700 | 0.84 | MCHR1 (0.44) | MCHR1KDM4ELMNAACACBHRH3 | |
| SCHEMBL1749316 | 0.84 | MCHR1 (0.43) | MCHR1KDM4ELMNAACACBHRH3 | |
| SCHEMBL1749691 | 0.84 | MCHR1 (0.43) | MCHR1KDM4ELMNAACACBHRH3 | |
| SCHEMBL1749251 | 0.83 | MCHR1 (0.45) | MCHR1KDM4ELMNAACACBPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7223788-B2 | therapy for eating disorders, anorexigenic agents, antidiabetic agents, reducing weight in mammals, circadian rhythm disease, psychological disorders | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-05-29 | — | — | US | disclosed |
| US-7223788-B2 | therapy for eating disorders, anorexigenic agents, antidiabetic agents, reducing weight in mammals, circadian rhythm disease, psychological disorders | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-05-29 | — | — | US | disclosed |