Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 3/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12528340 | 1.00 | KDM4E (0.53) | KDM4ELMNANPSR1MCHR1HSD17B10 | |
| SCHEMBL1750535 | 0.98 | KDM4E (0.51) | KDM4ELMNANPSR1MCHR1HSD17B10 | |
| SCHEMBL1750463 | 0.89 | MCHR1 (0.42) | KDM4ELMNANPSR1MCHR1ALDH1A1 | |
| SCHEMBL12528284 | 0.89 | MCHR1 (0.42) | KDM4ELMNANPSR1MCHR1ALDH1A1 | |
| SCHEMBL12547560 | 0.89 | MCHR1 (0.42) | KDM4ELMNANPSR1MCHR1ALDH1A1 | |
| SCHEMBL1750070 | 0.88 | ALDH1A1 (0.42) | KDM4ELMNAMCHR1ALDH1A1TSHR | |
| SCHEMBL1749700 | 0.88 | MCHR1 (0.44) | KDM4ELMNAMCHR1ALDH1A1HRH3 | |
| SCHEMBL1749251 | 0.88 | MCHR1 (0.45) | KDM4ELMNAMCHR1HRH3 | |
| SCHEMBL2636842 | 0.88 | HRH3 (0.46) | MCHR1ALDH1A1HRH3 | |
| SCHEMBL2637268 | 0.88 | HRH3 (0.46) | MCHR1ALDH1A1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7223788-B2 | therapy for eating disorders, anorexigenic agents, antidiabetic agents, reducing weight in mammals, circadian rhythm disease, psychological disorders | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-05-29 | — | — | US | disclosed |
| US-7223788-B2 | therapy for eating disorders, anorexigenic agents, antidiabetic agents, reducing weight in mammals, circadian rhythm disease, psychological disorders | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-05-29 | — | — | US | disclosed |