Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.49 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31238504 | 0.85 | SOS1 (0.54) | PARP10PARP3POLBCASP6ALDH1A1 | |
| SCHEMBL4853836 | 0.85 | SOS1 (0.54) | PARP10PARP3POLBCASP6ALDH1A1 | |
| SCHEMBL8545768 | 0.82 | PARP10 (0.50) | PARP10PARP3POLBCASP6ALDH1A1 | |
| SCHEMBL6142802 | 0.82 | PARP10 (0.50) | PARP10PARP3POLBCASP6ALDH1A1 | |
| SCHEMBL1663469 | 0.81 | PARP10 (0.65) | PARP10PARP3POLBCASP6ALDH1A1 | |
| SCHEMBL5050902 | 0.81 | PARP10 (0.65) | PARP10PARP3POLBCASP6ALDH1A1 | |
| SCHEMBL9103436 | 0.80 | ALDH1A1 (0.46) | PARP10PARP3POLBCASP6ALDH1A1 | |
| SCHEMBL14661923 | 0.80 | POLB (0.50) | PARP10PARP3POLBCASP6ALDH1A1 | |
| SCHEMBL14663508 | 0.80 | TUBB1 (0.47) | POLBALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL184204 | 0.79 | ALDH1A1 (0.62) | PARP10PARP3POLBCASP6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016019588-A1 | OXACAZONE COMPOUNDS TO TREAT CLOSTRIDIUM DIFFICILE | THE BROAD INSTITUTE, INC. (US) | 2016-02-11 | — | — | WO | disclosed |
| WO-2016019588-A1 | OXACAZONE COMPOUNDS TO TREAT CLOSTRIDIUM DIFFICILE | THE BROAD INSTITUTE, INC. (US) | 2016-02-11 | — | — | WO | disclosed |