SCHEMBL17508253

SCHEMBL17508253

Nc1ccc(Nc2cccc(O)c2)cc1N

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.62
TSHR P16473 1/20 0.62
HDAC6 Q9UBN7 1/20 0.52
KMT2A Q03164 5/20 0.49
ALDH1A1 P00352 4/20 0.49
MEN1 O00255 3/20 0.49
TDP1 Q9NUW8 3/20 0.49
ALOX15 P16050 2/20 0.49
CYP1A2 P05177 2/20 0.49
MAPT P10636 2/20 0.49
USP2 O75604 1/20 0.49
APP P05067 1/20 0.49
HSP90AA1 P07900 1/20 0.49
HSP90AB1 P08238 1/20 0.49
CYP2D6 P10635 1/20 0.49
CYP2C9 P11712 1/20 0.49
ALOX12 P18054 1/20 0.49
MAPK1 P28482 1/20 0.49
CYP2C19 P33261 1/20 0.49
SNCA P37840 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL563902 0.89 CYP3A4 (0.62) CYP3A4TSHRHDAC6KMT2AALDH1A1
SCHEMBL564726 0.87 CYP3A4 (0.60) CYP3A4TSHRHDAC6KMT2AALDH1A1
SCHEMBL17508260 0.84 RAPGEF4 (0.57) CYP3A4TSHRHDAC6KMT2AALDH1A1
SCHEMBL1920769 0.83 CYP3A4 (0.86) CYP3A4TSHRHDAC6KMT2AALDH1A1
SCHEMBL30026816 0.83 CYP3A4 (0.86) CYP3A4TSHRHDAC6KMT2AALDH1A1
SCHEMBL1389429 0.83 CYP3A4 (0.86) CYP3A4TSHRHDAC6KMT2AALDH1A1
SCHEMBL11475061 0.82 CYP3A4 (0.70) CYP3A4TSHRHDAC6KMT2AALDH1A1
SCHEMBL13302358 0.81 CYP3A4 (0.82) CYP3A4TSHRHDAC6KMT2AALDH1A1
SCHEMBL17414842 0.80 MAPT (0.67) CYP3A4KMT2AALDH1A1MEN1TDP1
SCHEMBL17508206 0.80 KMT2A (0.67) CYP3A4TSHRHDAC6KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016020112-A1 OXIDATION DYE PRECURSOR HENKEL AG & CO. KGAA (DE) 2016-02-11 WO claimed
WO-2016020112-A1 OXIDATION DYE PRECURSOR HENKEL AG & CO. KGAA (DE) 2016-02-11 WO disclosed
WO-2016020112-A1 OXIDATION DYE PRECURSOR HENKEL AG & CO. KGAA (DE) 2016-02-11 WO disclosed