Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 15/20 | 0.77 |
| ▸ | CA2 | P00918 | 15/20 | 0.77 |
| ▸ | CA9 | Q16790 | 10/20 | 0.77 |
| ▸ | CA12 | O43570 | 8/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.76 |
| ▸ | MEN1 | O00255 | 1/20 | 0.76 |
| ▸ | CA4 | P22748 | 2/20 | 0.71 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | CA7 | P43166 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6254979 | 0.87 | CA1 (1.00) | CA1CA2CA9CA12KMT2A | |
| SCHEMBL7440868 | 0.86 | PRMT1 (0.74) | CA1CA2CA9CA12KMT2A | |
| SCHEMBL5805800 | 0.83 | KMT2A (0.76) | CA1CA2CA9CA12KMT2A | |
| Sulfasuccinamide SCHEMBL20118963 | 0.83 | CA1 (1.00) | CA1CA2CA9CA12KMT2A | |
| SCHEMBL5805803 | 0.83 | CA1 (1.00) | CA1CA2CA9CA12KMT2A | |
| SCHEMBL31195239 | 0.81 | CA1 (0.71) | CA1CA2CA9CA12KMT2A | |
| SCHEMBL9780028 | 0.81 | CA1 (1.00) | CA1CA2CA9CA12KMT2A | |
| SCHEMBL7821516 | 0.81 | CA1 (0.82) | CA1CA2CA9CA12KMT2A | |
| SCHEMBL28093468 | 0.81 | CA1 (0.55) | CA1CA2CA9CA12KMT2A | |
| SCHEMBL11792732 | 0.81 | CA1 (0.82) | CA1CA2CA9CA12KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2987533-A1 | 7-substituted piperazin-1-yl fluoroquinolone compounds, their use in the treatment of cancer, pharmaceutical compositions and a method for preparation | King Saud University (SA) | 2016-02-24 | — | — | EP | claimed |
| EP-2987533-B1 | 7-substituted piperazin-1-yl fluoroquinolone compounds, their use in the treatment of cancer, pharmaceutical compositions and a method for preparation | UNIV KING SAUD (SA) | 2018-07-11 | — | — | EP | disclosed |
| EP-2987533-A1 | 7-substituted piperazin-1-yl fluoroquinolone compounds, their use in the treatment of cancer, pharmaceutical compositions and a method for preparation | King Saud University (SA) | 2016-02-24 | — | — | EP | disclosed |