Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 11/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2322270 | 0.91 | S1PR1 (0.44) | S1PR1S1PR4S1PR5MAPK1S1PR3 | |
| Hydrochloric Acid SCHEMBL2385356 | 0.91 | S1PR1 (0.43) | S1PR1S1PR4S1PR5MAPK1S1PR3 | |
| SCHEMBL17510093 | 0.90 | MAPK1 (0.40) | S1PR1S1PR4S1PR5MAPK1ALOX5 | |
| SCHEMBL2385531 | 0.88 | L3MBTL1 (0.48) | S1PR1MAPK1L3MBTL1 | |
| SCHEMBL10089083 | 0.87 | S1PR1 (0.46) | S1PR1S1PR4S1PR5ALOX5S1PR3 | |
| SCHEMBL10088839 | 0.87 | S1PR1 (0.43) | S1PR1S1PR4S1PR5ALOX5FFAR1 | |
| SCHEMBL10089061 | 0.87 | S1PR1 (0.46) | S1PR1S1PR4S1PR5S1PR3 | |
| SCHEMBL10310529 | 0.86 | S1PR1 (0.49) | S1PR1S1PR4S1PR5MAPK1S1PR3 | |
| SCHEMBL10088825 | 0.86 | S1PR1 (0.49) | S1PR1S1PR4S1PR5MAPK1S1PR3 | |
| SCHEMBL10089066 | 0.86 | S1PR1 (0.47) | S1PR1S1PR4S1PR5ALOX5FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2354134-B1 | 2H-CHROMENE DERIVATIVES AS STIMULATORS OF SPHINGOSINE 1-PHOSPHATE RECEPTOR | ASTELLAS PHARMA INC (JP) | 2016-02-24 | — | — | EP | claimed |