Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 4/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.40 |
| ▸ | CDK2 | P24941 | 4/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 4/20 | 0.33 |
| ▸ | SGK1 | O00141 | 1/20 | 0.33 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.33 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17514102 | 0.79 | CCNA2 (0.34) | CCNA2CDK2CCNA1 | |
| SCHEMBL24566893 | 0.78 | CHEK1 (0.35) | CCNA2CDK2CCNA1HCAR2 | |
| Hydrochloric Acid SCHEMBL29900907 | 0.77 | PLAT (0.41) | AXLSGK1CAMKK2 | |
| SCHEMBL17514144 | 0.76 | KDM4E (0.42) | HCAR3CDK2NAPRTMGAMKDM4E | |
| SCHEMBL1145007 | 0.75 | HCAR3 (0.41) | HCAR3HCAR2KDM4AKDM4CNAPRT | |
| SCHEMBL28586933 | 0.75 | HCAR2 (0.41) | HCAR3HCAR2KDM4AKDM4CAXL | |
| SCHEMBL1592938 | 0.75 | GRM4 (0.32) | — | |
| SCHEMBL30692607 | 0.75 | HCAR3 (0.41) | HCAR3HCAR2KDM4AKDM4CNAPRT | |
| SCHEMBL22368670 | 0.75 | PDK2 (0.47) | KDM4E | |
| SCHEMBL30592406 | 0.75 | JAK2 (0.39) | CCNA2CDK2CCNA1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3183239-B1 | INDAZOLES | MERCK PATENT GMBH (DE) | 2018-09-26 | — | — | EP | disclosed |
| US-9862717-B2 | Indazoles | MERCK PATENT GMBH (DE) | 2018-01-09 | — | — | US | disclosed |
| US-20170267675-A1 | INDAZOLES | MERCK PATENT GMBH (DE) | 2017-09-21 | — | — | US | disclosed |
| EP-3183239-A1 | INDAZOLES | Merck Patent GmbH (DE) | 2017-06-28 | — | — | EP | disclosed |
| WO-2016026549-A1 | INDAZOLES | MERCK PATENT GMBH (DE) | 2016-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170267675-A1 | INDAZOLES | MKI67, CCNI, BRCA1 | HCAR3 1194/4885CCNA2 105/4885CDK2 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.