Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | GRK6 | P43250 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL166231 | 0.86 | NTRK1 (0.44) | NTRK1GRK6 | |
| SCHEMBL174383 | 0.85 | PRKCI (0.34) | — | |
| SCHEMBL175046 | 0.80 | PAK4 (0.33) | — | |
| SCHEMBL174490 | 0.78 | AURKB (0.41) | NTRK1GRK6MEN1KMT2A | |
| SCHEMBL174171 | 0.77 | NTRK1 (0.41) | NTRK1MEN1KMT2A | |
| SCHEMBL174445 | 0.76 | CCNE2 (0.44) | NTRK1GRK6MEN1KMT2A | |
| SCHEMBL174795 | 0.76 | FLT3 (0.36) | NTRK1MEN1KMT2A | |
| SCHEMBL173271 | 0.75 | AURKB (0.44) | NTRK1GRK6MEN1KMT2A | |
| SCHEMBL13011344 | 0.75 | CTNNB1 (0.38) | NTRK1GRK6MEN1KMT2A | |
| SCHEMBL175164 | 0.72 | MEN1 (0.38) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611812-A1 | THIENOPYRIDINE AND THIENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2013-07-10 | — | — | EP | claimed |
| WO-2012030894-A1 | THIENOPYRIDINE AND THIENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2012-03-08 | — | — | WO | claimed |
| EP-2611812-A1 | THIENOPYRIDINE AND THIENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030894-A1 | THIENOPYRIDINE AND THIENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2012-03-08 | — | — | WO | disclosed |