Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.74 |
| ▸ | HDAC2 | Q92769 | 12/20 | 0.74 |
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.74 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.52 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17520538 | 0.88 | HDAC6 (0.81) | HDAC6HDAC2HDAC8HDAC3HDAC4 | |
| SCHEMBL20629265 | 0.88 | HDAC6 (0.78) | HDAC6HDAC2HDAC8HDAC3HDAC4 | |
| SCHEMBL17520533 | 0.85 | HDAC6 (1.00) | HDAC6HDAC2HDAC8HDAC3HDAC4 | |
| SCHEMBL17520543 | 0.85 | HDAC6 (1.00) | HDAC6HDAC2HDAC8HDAC3HDAC4 | |
| SCHEMBL19161111 | 0.83 | HDAC6 (0.73) | HDAC6HDAC2HDAC8HDAC3HDAC4 | |
| SCHEMBL24011804 | 0.82 | HDAC6 (0.75) | HDAC6HDAC2HDAC8HDAC3HDAC4 | |
| SCHEMBL17520445 | 0.81 | HDAC6 (0.70) | HDAC6HDAC2HDAC8HDAC3HDAC4 | |
| SCHEMBL24011764 | 0.79 | HDAC6 (0.60) | HDAC6HDAC2HDAC8HDAC3HDAC4 | |
| SCHEMBL17520537 | 0.77 | HDAC6 (0.70) | HDAC6HDAC2HDAC8HDAC3HDAC4 | |
| SCHEMBL24011824 | 0.72 | HDAC6 (0.72) | HDAC6HDAC2HDAC8HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016020369-A1 | NOVEL HDAC6 INHIBITORS AND THEIR USES | UNIVERSITÄT REGENSBURG (DE) | 2016-02-11 | — | — | WO | disclosed |