Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 20/20 | 0.78 |
| ▸ | HDAC2 | Q92769 | 16/20 | 0.78 |
| ▸ | HDAC8 | Q9BY41 | 14/20 | 0.78 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17520643 | 0.88 | HDAC6 (0.74) | HDAC6HDAC2HDAC8HDAC3HDAC1 | |
| SCHEMBL17520533 | 0.88 | HDAC6 (1.00) | HDAC6HDAC2HDAC8HDAC3HDAC1 | |
| SCHEMBL17520543 | 0.88 | HDAC6 (1.00) | HDAC6HDAC2HDAC8HDAC3HDAC1 | |
| SCHEMBL17520538 | 0.86 | HDAC6 (0.81) | HDAC6HDAC2HDAC8HDAC3HDAC1 | |
| SCHEMBL19161111 | 0.82 | HDAC6 (0.73) | HDAC6HDAC2HDAC8HDAC3HDAC1 | |
| SCHEMBL24011764 | 0.81 | HDAC6 (0.60) | HDAC6HDAC2HDAC8HDAC3HDAC1 | |
| SCHEMBL17520445 | 0.80 | HDAC6 (0.70) | HDAC6HDAC2HDAC8HDAC3HDAC1 | |
| SCHEMBL20629459 | 0.78 | HDAC6 (0.78) | HDAC6HDAC2HDAC8HDAC3HDAC1 | |
| SCHEMBL17520537 | 0.77 | HDAC6 (0.70) | HDAC6HDAC2HDAC8HDAC3HDAC1 | |
| SCHEMBL20629476 | 0.75 | HDAC6 (0.79) | HDAC6HDAC2HDAC8HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3177621-B1 | NOVEL HDAC6 INHIBITORS AND THEIR USES | UNIV REGENSBURG (DE) | 2021-11-10 | — | — | EP | disclosed |
| EP-3424925-A1 | NOVEL HDAC6 INHIBITORS, WITH IMPROVED SOLUBILITY AND THEIR USES | Universität Regensburg (DE) | 2019-01-09 | — | — | EP | disclosed |