Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY2 | P41231 | 3/20 | 0.42 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.42 |
| ▸ | P2RX1 | P51575 | 3/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.41 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.41 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.40 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.40 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.40 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.40 |
| ▸ | RNASEL | Q05823 | 3/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
| ▸ | ENTPD1 | P49961 | 1/20 | 0.39 |
| ▸ | POLRMT | O00411 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17522719 | 0.89 | POLRMT (0.45) | P2RY2P2RY4P2RX1P2RX3P2RX4 | |
| SCHEMBL15682898 | 0.89 | P2RX1 (0.46) | P2RY2P2RX1P2RX3P2RX4P2RX2 | |
| SCHEMBL17124607 | 0.88 | P2RY2 (0.40) | P2RY2P2RY4P2RX1P2RX3P2RX4 | |
| SCHEMBL17522701 | 0.88 | P2RY2 (0.45) | P2RY2P2RY4P2RX1P2RX3P2RX4 | |
| SCHEMBL15682895 | 0.81 | POLRMT (0.55) | P2RY2P2RY4P2RX1P2RX3P2RX4 | |
| SCHEMBL12254003 | 0.81 | P2RY2 (0.45) | P2RY2P2RY4P2RX1P2RX3P2RX4 | |
| SCHEMBL881477 | 0.80 | P2RX1 (0.44) | P2RX1P2RX3P2RX4P2RX2P2RY1 | |
| SCHEMBL17522702 | 0.80 | P2RY2 (0.41) | P2RY2P2RY4P2RX1P2RX3P2RX4 | |
| SCHEMBL15682896 | 0.80 | POLRMT (0.52) | P2RX1P2RX3P2RX4P2RX2P2RY1 | |
| SCHEMBL7598980 | 0.79 | P2RY2 (0.51) | P2RY2P2RY4P2RX1P2RX3P2RX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9457039-B2 | 2′-disubstituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases | MERCK SHARP & DOHME CORP. (US) | 2016-10-04 | — | — | US | disclosed |
| US-20160045526-A1 | 2'-DISUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME CORP. (US) | 2016-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160045526-A1 | 2'-DISUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | SLC28A2, SLC28A1, SLC29A2 | P2RY2 275/4885P2RY4 412/4885P2RX1 247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.