Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 7/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 7/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14765182 | 0.89 | LPL (0.39) | LPLLIPGIRAK4ROCK1PRMT5 | |
| SCHEMBL14764793 | 0.83 | ROCK1 (0.36) | LPLLIPGROCK1 | |
| SCHEMBL14765057 | 0.76 | LPL (0.31) | LPLLIPG | |
| SCHEMBL34463705 | 0.75 | KMT2A (0.38) | — | |
| SCHEMBL17522841 | 0.75 | PIK3CA (0.41) | — | |
| SCHEMBL30219059 | 0.67 | LPL (0.40) | LPLLIPGIRAK4ROCK1CA1 | |
| SCHEMBL21913269 | 0.67 | ROCK1 (0.35) | LPLLIPGIRAK4ROCK1PRMT5 | |
| SCHEMBL23986897 | 0.66 | LPL (0.39) | LPLLIPGROCK1PRMT5WDR77 | |
| SCHEMBL16581306 | 0.66 | LPL (0.56) | LPLLIPGIRAK4ROCK1PRMT5 | |
| SCHEMBL29392121 | 0.66 | LPL (0.75) | LPLLIPGIRAK4ROCK1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9265773-B2 | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases | MERCK SHARP & DOHME CORP. (US) | 2016-02-23 | — | — | US | disclosed |