⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL966301 | 0.95 | EPHX1 (0.59) | — | |
| SCHEMBL19312134 | 0.93 | EPHX1 (0.62) | — | |
| Hydrochloric Acid SCHEMBL28201975 | 0.93 | EPHX1 (0.57) | — | |
| SCHEMBL967500 | 0.93 | EPHX1 (0.62) | — | |
| SCHEMBL16230019 | 0.93 | EPHX1 (0.62) | — | |
| SCHEMBL8391708 | 0.93 | EPHX1 (0.62) | — | |
| SCHEMBL24268428 | 0.92 | EPHX1 (0.47) | — | |
| SCHEMBL10810342 | 0.90 | EPHX1 (0.47) | — | |
| SCHEMBL103736 | 0.90 | — | — | |
| Hydrochloric Acid SCHEMBL28974203 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903979-B1 | NOVEL COMPOUNDS, THEIR PREPARATION AND THEIR USES | INHIBIKASE THERAPEUTICS INC (US) | 2020-08-19 | — | — | EP | claimed |
| CN-113292535-B | Method for preparing apaluamide intermediate and apaluamide | 南京方生和医药科技有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-113993519-A | Degradation agent for cyclin dependent kinase 12(CDK12) and use thereof | 达纳-法伯癌症研究公司 | 2022-01-28 | — | — | CN | disclosed |
| CN-113292535-A | Method for preparing apaluamide intermediate and apaluamide | 南京方生和医药科技有限公司 | 2021-08-24 | — | — | CN | disclosed |
| CN-110049979-A | BROMODOMAIN INHIBITORS | 艾伯维公司 | 2019-07-23 | — | — | CN | disclosed |
| CN-104507910-B | Partially saturated nitrogen-containing heterocyclic compound | 大正制药株式会社 | 2016-06-15 | — | — | CN | disclosed |
| CN-104507910-A | Partially saturated nitrogen-containing heterocyclic compound | TAISHO PHARMACEUTICAL CO LTD | 2015-04-08 | — | — | CN | disclosed |
| US-8906852-B2 | Inhibitors of protein tyrosine kinase activity | METHYLGENE INC. (CA) | 2014-12-09 | — | — | US | disclosed |
| US-20140315801-A1 | METHODS OF TREATMENT OF CELL PROLIFERATIVE AND/OR OPHTHALMIC DISEASES, DISORDERS AND CONDITIONS USING INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY | METHYLGENE INC (CA) | 2014-10-23 | — | — | US | disclosed |
| US-20140179632-A1 | METHODS OF INHIBITING PROTEIN TYROSINE KINASE ACTIVITY | METHYLGENE INC. (CA) | 2014-06-26 | — | — | US | disclosed |
| US-20080146643-A1 | COMBINATION | PFIZER LIMITED (GB) | 2008-06-19 | — | — | US | disclosed |
| WO-2008072053-A2 | SUBSTITUTED ARYLPYRAZOLES | PFIZER LIMITED (GB) | 2008-06-19 | — | — | WO | disclosed |
| WO-2008072077-A2 | COMBINATION OF 1-ARYL-4-CYCLOPROPYLPYRAZOLES WITH ANTHELMINTIC AGENT FOR PARASITIC INFESTATION | PFIZER LIMITED (GB) | 2008-06-19 | — | — | WO | disclosed |
| EP-1893581-A1 | SUBSTITUTED ARYLPYRAZOLES FOR USE AGAINST PARASITITES | Pfizer Limited (GB) | 2008-03-05 | — | — | EP | disclosed |
| US-20070149464-A1 | COMBINATION | PFIZER INC. (US) | 2007-06-28 | — | — | US | disclosed |
| US-20070149550-A1 | 1-aryl-4-cyclopropylpyrazoles with at least one fluorine attached to the cyclopropyl ring; parasiticides; fleas; extended duration of action for at least 28 days | PFIZER INC. (US) | 2007-06-28 | — | — | US | disclosed |
| US-20060287365-A1 | Substituted arylpyrazoles | ZOETIS LLC | 2006-12-21 | — | — | US | disclosed |
| WO-2006134468-A1 | SUBSTITUTED ARYLPYRAZOLES FOR USE AGAINST PARASITITES | PFIZER LIMITED (GB) | 2006-12-21 | — | — | WO | disclosed |
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |