Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PREP | P48147 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12468980 | 0.86 | MEN1 (0.53) | HRH3ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL8210703 | 0.86 | KMT2A (0.55) | ALDH1A1TP53THRBMAPTMEN1 | |
| SCHEMBL3863834 | 0.83 | KMT2A (0.63) | ALDH1A1TP53THRBMAPTMEN1 | |
| SCHEMBL12469354 | 0.81 | HRH3 (0.48) | HRH3ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL19222444 | 0.81 | HRH3 (0.48) | HRH3ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL2862442 | 0.81 | ALDH1A1 (0.60) | ALDH1A1TP53THRBMAPTMEN1 | |
| SCHEMBL23341424 | 0.80 | TP53 (0.45) | TP53THRBMAPTKDM4E | |
| SCHEMBL3396768 | 0.80 | HSD17B10 (0.60) | ALDH1A1TP53THRBMAPTMEN1 | |
| SCHEMBL3396771 | 0.80 | HSD17B10 (0.60) | ALDH1A1TP53THRBMAPTMEN1 | |
| SCHEMBL18608789 | 0.80 | MEN1 (0.58) | HRH3TP53MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220348577-A1 | CXCR4 Receptor Antagonists | PROXIMAGEN LLC (US) | 2022-11-03 | — | — | US | disclosed |
| US-20170226106-A1 | CXCR4 Receptor Antagonists | PROXIMAGEN, LLC | 2017-08-10 | — | — | US | disclosed |
| US-20170226106-A1 | CXCR4 Receptor Antagonists | PROXIMAGEN, LLC | 2017-08-10 | — | — | US | disclosed |
| US-9353086-B2 | CXCR4 receptor antagonists | PROXIMAGEN LIMITED (GB) | 2016-05-31 | — | — | US | disclosed |
| US-20160046606-A1 | CXCR4 Receptor Antagonists | PROXIMAGEN LIMITED (GB) | 2016-02-18 | — | — | US | disclosed |
| CN-103282360-A | Cxcr4 receptor antagonists | PROXIMAGEN LTD | 2013-09-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170226106-A1 | CXCR4 Receptor Antagonists | CXCR4, CXCR1, CXCR2 | HRH3 288/4885ALDH1A1 886/4885TP53 3543/4885 |
| US-20220348577-A1 | CXCR4 Receptor Antagonists | CXCR4, CXCR1, CXCR2 | HRH3 288/4885ALDH1A1 886/4885TP53 3543/4885 |
| US-20160046606-A1 | CXCR4 Receptor Antagonists | CXCR4, CXCR1, CXCR2 | HRH3 288/4885ALDH1A1 886/4885TP53 3543/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.