Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 9/20 | 0.58 |
| ▸ | PRKCD | Q05655 | 7/20 | 0.58 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 8/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9882005 | 0.89 | PRKCQ (0.70) | PRKCQPRKCDPIM1PIM3PIM2 | |
| SCHEMBL8509439 | 0.86 | PRKCQ (0.59) | PRKCQPRKCDPIM1 | |
| SCHEMBL8509447 | 0.86 | PRKCQ (0.59) | PRKCQPRKCDPIM1 | |
| SCHEMBL9882354 | 0.84 | PRKCQ (0.57) | PRKCQPRKCDPIM1 | |
| SCHEMBL17525868 | 0.83 | PIM1 (0.53) | PRKCQPRKCDPIM1PIM3PIM2 | |
| SCHEMBL9882113 | 0.81 | PRKCQ (0.62) | PRKCQPRKCDPIM1PIM3PIM2 | |
| SCHEMBL15275352 | 0.79 | PRKCQ (0.55) | PRKCQPRKCDZAP70HDAC1 | |
| SCHEMBL15273942 | 0.79 | PRKCQ (0.41) | PRKCQPRKCDPIM1PIM3PIM2 | |
| SCHEMBL9882049 | 0.79 | PRKCQ (0.55) | PRKCQPRKCDZAP70HDAC1 | |
| SCHEMBL9882396 | 0.78 | PIM1 (0.43) | PRKCQPRKCDPIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318408-B1 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS | VERTEX PHARMA (US) | 2016-02-17 | — | — | EP | disclosed |