Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 15/20 | 0.67 |
| ▸ | INSR | P06213 | 4/20 | 0.67 |
| ▸ | TTK | P33981 | 4/20 | 0.67 |
| ▸ | FES | P07332 | 3/20 | 0.67 |
| ▸ | FLT3 | P36888 | 3/20 | 0.67 |
| ▸ | IGF1R | P08069 | 3/20 | 0.67 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.67 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.67 |
| ▸ | PLK4 | O00444 | 2/20 | 0.67 |
| ▸ | GAK | O14976 | 2/20 | 0.67 |
| ▸ | ERN1 | O75460 | 2/20 | 0.67 |
| ▸ | STK10 | O94804 | 2/20 | 0.67 |
| ▸ | ABL1 | P00519 | 2/20 | 0.67 |
| ▸ | EGFR | P00533 | 2/20 | 0.67 |
| ▸ | LCK | P06239 | 2/20 | 0.67 |
| ▸ | FYN | P06241 | 2/20 | 0.67 |
| ▸ | YES1 | P07947 | 2/20 | 0.67 |
| ▸ | HCK | P08631 | 2/20 | 0.67 |
| ▸ | ROS1 | P08922 | 2/20 | 0.67 |
| ▸ | FER | P16591 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1493627 | 0.94 | ALK (0.68) | ALKINSRTTKFESFLT3 | |
| SCHEMBL17527331 | 0.94 | ALK (0.63) | ALKINSRTTKFESFLT3 | |
| SCHEMBL1493628 | 0.89 | ALK (0.68) | ALKINSRTTKFESFLT3 | |
| SCHEMBL11900488 | 0.87 | ALK (0.64) | ALKINSRTTKFESFLT3 | |
| SCHEMBL22515548 | 0.87 | ZAP70 (0.63) | ALKINSRTTKFESFLT3 | |
| SCHEMBL11916359 | 0.85 | ALK (0.56) | ALKINSRTTKFESFLT3 | |
| SCHEMBL11916498 | 0.84 | ALK (0.83) | ALKINSRTTKFESFLT3 | |
| SCHEMBL11900490 | 0.84 | ALK (0.63) | ALKINSRTTKFESFLT3 | |
| SCHEMBL17527459 | 0.82 | ALK (0.58) | ALKINSRTTKFESFLT3 | |
| Tae-684 SCHEMBL282775 | 0.80 | ALK (1.00) | ALKINSRTTKFESFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9273077-B2 | Phosphorus derivatives as kinase inhibitors | ARIAD PHARMACEUTICALS, INC. (US) | 2016-03-01 | — | — | US | claimed |