Tae-684

Tae-684

SCHEMBL282775

COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALK Q9UM73 17/20 1.00
INSR P06213 8/20 1.00
IGF1R P08069 7/20 1.00
EGFR P00533 4/20 1.00
FGFR1 P11362 2/20 1.00
FGFR2 P21802 2/20 1.00
FGFR4 P22455 2/20 1.00
FGFR3 P22607 2/20 1.00
BMPR1B O00238 2/20 1.00
PLK4 O00444 2/20 1.00
GAK O14976 2/20 1.00
ERN1 O75460 2/20 1.00
STK10 O94804 2/20 1.00
ABL1 P00519 2/20 1.00
LCK P06239 2/20 1.00
FYN P06241 2/20 1.00
FES P07332 2/20 1.00
YES1 P07947 2/20 1.00
HCK P08631 2/20 1.00
ROS1 P08922 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tae-684 SCHEMBL29641017 1.00 ALK (1.00) ALKINSRIGF1REGFRFGFR1
SCHEMBL12780522 0.95 ALK (1.00) ALKINSRIGF1REGFRFGFR1
SCHEMBL12892781 0.94 ALK (0.91) ALKINSRIGF1REGFRFGFR1
SCHEMBL12781735 0.94 ALK (0.88) ALKINSRIGF1REGFRFGFR1
SCHEMBL18843559 0.93 ALK (0.87) ALKINSRIGF1REGFRFGFR1
SCHEMBL24301100 0.93 ALK (0.87) ALKINSRIGF1REGFRFGFR1
SCHEMBL4098937 0.92 ALK (0.85) ALKINSRIGF1REGFRFGFR1
SCHEMBL22493267 0.92 ALK (0.85) ALKINSRIGF1REGFRFGFR1
SCHEMBL21478104 0.92 ALK (0.87) ALKINSRIGF1REGFRFGFR1
SCHEMBL15217778 0.91 ALK (0.84) ALKINSRIGF1REGFRFGFR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1148 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12522873-B2 ALK and NTRK1 fusion molecules and uses thereof FOUNDATION MEDICINE, INC. (US) 2026-01-13 US claimed
EP-4673149-A1 NEW COMPOUNDS AND TREATMENT OF RENAL CELL CARCINOMA Trustlife Global Inc. (US) 2026-01-07 EP claimed
US-12378302-B2 Fusion molecules and uses thereof FOUNDATION MEDICINE, INC. (US) 2025-08-05 US claimed
US-20250186432-A1 SPLEEN TYROSINE KINASE INHIBITOR, COMPOSITION, AND METHODS OF USE PURDUE RESEARCH FOUNDATION 2025-06-12 US claimed
US-20250188041-A1 NEW COMPOUNDS AND TREATMENT OF RENAL CELL CARCINOMA Trustlife Global Inc. 2025-06-12 US claimed
US-20250146076-A1 ALK GENE FUSIONS AND USES THEREOF FOUNDATION MEDICINE, INC. (US) 2025-05-08 US claimed
WO-2025096061-A1 CDK2 INHIBITORS AND USES THEREOF ODYSSEY THERAPEUTICS, INC. (US) 2025-05-08 WO claimed
US-20250129430-A1 HIGH ATP-AFFINITY PROTEIN AS THERAPEUTIC TARGET FOR INTRACTABLE CANCER MOLECULAR SUBTYPES AND INHIBITOR THEREOF VeraVerse Co., Ltd. (KR) 2025-04-24 US claimed
US-20250129429-A1 GENE FUSIONS IN SARCOMA FOUNDATION MEDICINE, INC. (US) 2025-04-24 US claimed
WO-2025054386-A1 CDK2 INHIBITORS AND USES THEREOF ODYSSEY THERAPEUTICS, INC. (US) 2025-03-13 WO claimed
US-20150184161-A1 EML4-ALK FUSION GENE ASTELLAS PHARMA INC. (JP) 2015-07-02 US claimed
WO-2014203152-A1 PHARMACEUTICAL COMBINATIONS NOVARTIS AG (CH) 2014-12-24 WO claimed
EP-2116553-B1 EML4-ALK fusion gene ASTELLAS PHARMA INC (JP) 2014-07-30 EP claimed
US-20130158095-A1 EML4-ALK FUSION GENE CUREGENE K.K. (JP) 2013-06-20 US claimed
US-20110230545-A1 EML4-ALK FUSION GENE ASTELLAS PHARMA INC. (JP) 2011-09-22 US claimed
US-20100240673-A1 EML4-ALK Fusion Gene ASTELLAS PHARMA INC. (JP) 2010-09-23 US claimed
EP-2116553-A1 EML4-ALK fusion gene Astellas Pharma Inc. (JP) 2009-11-11 EP claimed
US-20090099193-A1 EML4-ALK FUSION GENE ASTELLAS PHARMA INC. (JP) 2009-04-16 US claimed
EP-1914240-A1 EML4-ALK fusion gene Astellas Pharma Inc. (JP) 2008-04-23 EP claimed
US-20080090776-A1 EML4-ALK FUSION GENE ASTELLAS PHARMA INC. (JP) 2008-04-17 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250186432-A1 SPLEEN TYROSINE KINASE INHIBITOR, COMPOSITION, AND METHODS OF USE SYK, BTK, G6PD ALK 1620/4885INSR 1946/4885IGF1R 1255/4885
US-20250188041-A1 NEW COMPOUNDS AND TREATMENT OF RENAL CELL CARCINOMA RCC2, GLS, VHL ALK 2234/4885INSR 2422/4885IGF1R 1774/4885
US-12378302-B2 Fusion molecules and uses thereof RPS27A, CD2BP2, FGB ALK 171/4885INSR 2259/4885IGF1R 3166/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.