Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 19/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.52 |
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1750624 | 0.83 | PDE4D (0.50) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL5022238 | 0.81 | PDE4B (0.69) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL5026648 | 0.80 | PDE4B (0.51) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL8298189 | 0.80 | PDE4B (0.62) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL6837997 | 0.78 | PDE4D (0.60) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL6837789 | 0.78 | PDE4D (0.68) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL1750806 | 0.77 | MAOA (0.50) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL5723067 | 0.77 | PDE4D (0.52) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL5722929 | 0.76 | PDE4D (0.69) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL1752409 | 0.76 | MAOA (0.51) | PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225205-B1 | ESTER DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMA SPA (IT) | 2013-01-02 | — | — | EP | disclosed |
| US-7968724-B2 | Ester derivatives as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-06-28 | — | — | US | disclosed |
| EP-2225205-A1 | ESTER DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.p.A. (IT) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009077068-A9 | ESTER DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMA SPA (IT) | 2009-08-20 | — | — | WO | disclosed |
| US-20090170903-A1 | ESTER DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-07-02 | — | — | US | disclosed |
| WO-2009077068-A1 | ESTER DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-06-25 | — | — | WO | disclosed |
| EP-2070913-A1 | Ester derivatives as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.p.A. (IT) | 2009-06-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170903-A1 | ESTER DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | PDE4A, PDE4B, PDE5A | PDE4D 5/4885PDE4B 2/4885PDE4A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.