Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 18/20 | 0.57 |
| ▸ | ROS1 | P08922 | 8/20 | 0.57 |
| ▸ | INSR | P06213 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11900446 | 0.92 | ALK (0.57) | ALKROS1INSRIGF1RZAP70 | |
| SCHEMBL11916357 | 0.82 | ALK (0.48) | ALKROS1INSR | |
| SCHEMBL17527331 | 0.81 | ALK (0.63) | ALKROS1INSRIGF1RZAP70 | |
| SCHEMBL11916442 | 0.81 | ALK (0.73) | ALKROS1INSRIGF1RZAP70 | |
| SCHEMBL17527349 | 0.81 | ALK (0.47) | ALKROS1INSRIGF1RZAP70 | |
| SCHEMBL11900888 | 0.79 | ALK (0.64) | ALKROS1INSRIGF1RZAP70 | |
| SCHEMBL11900488 | 0.79 | ALK (0.64) | ALKROS1INSRIGF1RZAP70 | |
| SCHEMBL11902141 | 0.78 | ALK (0.77) | ALKROS1INSRIGF1RZAP70 | |
| SCHEMBL17527319 | 0.78 | ALK (0.67) | ALKROS1INSRIGF1RZAP70 | |
| SCHEMBL15207208 | 0.78 | ALK (0.68) | ALKROS1INSRIGF1RZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9273077-B2 | Phosphorus derivatives as kinase inhibitors | ARIAD PHARMACEUTICALS, INC. (US) | 2016-03-01 | — | — | US | claimed |