⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16914406 | 1.00 | — | — | |
| SCHEMBL6129777 | 0.73 | — | — | |
| SCHEMBL24622108 | 0.69 | — | — | |
| SCHEMBL24373088 | 0.68 | — | — | |
| SCHEMBL24373752 | 0.68 | — | — | |
| SCHEMBL23477959 | 0.66 | POLB (0.46) | — | |
| SCHEMBL23478106 | 0.66 | POLB (0.46) | — | |
| SCHEMBL25736980 | 0.65 | — | — | |
| SCHEMBL24372980 | 0.64 | — | — | |
| SCHEMBL24372981 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10221170-B2 | Difluoropyrrolidines as orexin receptor modulators | EOLAS THERAPEUTICS, INC. (US) | 2019-03-05 | — | — | US | disclosed |
| US-20170226103-A1 | DIFLUOROPYRROLIDINES AS OREXIN RECEPTOR MODULATORS | NIUVERA BIO, INC. | 2017-08-10 | — | — | US | disclosed |
| US-20170226103-A1 | DIFLUOROPYRROLIDINES AS OREXIN RECEPTOR MODULATORS | NIUVERA BIO, INC. | 2017-08-10 | — | — | US | disclosed |
| WO-2016025669-A1 | DIFLUOROPYRROLIDINES AS OREXIN RECEPTOR MODULATORS | EOLAS THERAPEUTICS, INC. (US) | 2016-02-18 | — | — | WO | disclosed |