Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 6/20 | 0.68 |
| ▸ | PPARG | P37231 | 3/20 | 0.68 |
| ▸ | PGR | P06401 | 3/20 | 0.68 |
| ▸ | ESR1 | P03372 | 2/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.54 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.54 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | ALB | P02768 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.51 |
| ▸ | APEX1 | P27695 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21307548 | 0.91 | NR1I2 (0.56) | NR1I2PPARGPGRESR1TDP1 | |
| SCHEMBL17528943 | 0.91 | NR1I2 (0.56) | NR1I2PPARGPGRESR1TDP1 | |
| SCHEMBL12968958 | 0.91 | NR1I2 (0.56) | NR1I2PPARGPGRESR1TDP1 | |
| SCHEMBL19407657 | 0.91 | NR1I2 (0.56) | NR1I2PPARGPGRESR1TDP1 | |
| Water SCHEMBL9343390 | 0.88 | NR1I2 (0.80) | NR1I2PPARGPGRESR1TDP1 | |
| Water SCHEMBL9343404 | 0.88 | NR1I2 (0.80) | NR1I2PPARGPGRESR1TDP1 | |
| SCHEMBL9640914 | 0.87 | NR1I2 (0.89) | NR1I2PPARGPGRESR1TDP1 | |
| SCHEMBL15500606 | 0.85 | MAPT (0.56) | NR1I2PPARGPGRESR1TDP1 | |
| SCHEMBL13403571 | 0.84 | NR1I2 (0.47) | NR1I2PPARGPGRESR1TDP1 | |
| Ceftazidime SCHEMBL22368513 | 0.84 | NR1I2 (0.90) | NR1I2PPARGPGRESR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170275300-A1 | SYNTHESIS OF CEPHALOSPORIN COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2017-09-28 | — | — | US | disclosed |
| WO-2016025839-A1 | SYNTHESIS OF CEPHALOSPORIN COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2016-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170275300-A1 | SYNTHESIS OF CEPHALOSPORIN COMPOUNDS | COASY, NRDC, NUCB2 | NR1I2 2678/4885PPARG 3862/4885PGR 2779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.