Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 5/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | PPARG | P37231 | 2/20 | 0.56 |
| ▸ | ALB | P02768 | 1/20 | 0.56 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.56 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.56 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.55 |
| ▸ | ESR1 | P03372 | 2/20 | 0.55 |
| ▸ | PGR | P06401 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | APEX1 | P27695 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12968958 | 1.00 | NR1I2 (0.56) | NR1I2HTR2CMAPTPPARGALB | |
| SCHEMBL21307548 | 1.00 | NR1I2 (0.56) | NR1I2HTR2CMAPTPPARGALB | |
| SCHEMBL17528943 | 1.00 | NR1I2 (0.56) | NR1I2HTR2CMAPTPPARGALB | |
| SCHEMBL17529039 | 0.91 | NR1I2 (0.68) | NR1I2HTR2CMAPTPPARGALB | |
| SCHEMBL9848034 | 0.91 | NR1I2 (0.45) | NR1I2HTR2CMAPTPPARGALB | |
| SCHEMBL12969278 | 0.91 | NR1I2 (0.45) | NR1I2HTR2CMAPTPPARGALB | |
| SCHEMBL8983019 | 0.91 | NR1I2 (0.45) | NR1I2HTR2CMAPTPPARGALB | |
| SCHEMBL19726067 | 0.91 | NR1I2 (0.45) | NR1I2HTR2CMAPTPPARGALB | |
| SCHEMBL8983035 | 0.91 | NR1I2 (0.45) | NR1I2HTR2CMAPTPPARGALB | |
| SCHEMBL8756835 | 0.90 | NR1I2 (0.67) | NR1I2HTR2CMAPTPPARGALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11059835-B2 | Synthesis of cephalosporin compounds | MERCK SHARP & DOHME CORP. (US) | 2021-07-13 | — | — | US | disclosed |
| US-20200385404-A1 | SYNTHESIS OF CEPHALOSPORIN COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2020-12-10 | — | — | US | disclosed |
| EP-3180347-B1 | SYNTHESIS OF CEPHALOSPORIN COMPOUNDS | MERCK SHARP & DOHME (US) | 2020-09-23 | — | — | EP | disclosed |
| US-20170275300-A1 | SYNTHESIS OF CEPHALOSPORIN COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2017-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200385404-A1 | SYNTHESIS OF CEPHALOSPORIN COMPOUNDS | COASY, DDT, PEPD | NR1I2 3775/4885HTR2C 3575/4885MAPT 3928/4885 |
| US-11059835-B2 | Synthesis of cephalosporin compounds | COASY, DDT, PEPD | NR1I2 3775/4885HTR2C 3575/4885MAPT 3928/4885 |
| US-20170275300-A1 | SYNTHESIS OF CEPHALOSPORIN COMPOUNDS | COASY, NRDC, NUCB2 | NR1I2 2678/4885HTR2C 3877/4885MAPT 4013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.