Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.55 |
| ▸ | JAK1 | P23458 | 2/20 | 0.55 |
| ▸ | TYK2 | P29597 | 2/20 | 0.55 |
| ▸ | JAK3 | P52333 | 2/20 | 0.55 |
| ▸ | SYK | P43405 | 3/20 | 0.48 |
| ▸ | CDK4 | P11802 | 3/20 | 0.43 |
| ▸ | CCND1 | P24385 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 2/20 | 0.42 |
| ▸ | CHUK | O15111 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13252147 | 0.89 | SLC6A4 (0.44) | JAK2JAK1TYK2JAK3CDK4 | |
| SCHEMBL12120870 | 0.89 | CDK4 (0.50) | JAK2JAK1TYK2JAK3CDK4 | |
| SCHEMBL1631902 | 0.86 | IKBKB (0.48) | JAK2JAK1TYK2JAK3SYK | |
| SCHEMBL1635098 | 0.84 | JAK2 (0.74) | JAK2JAK1TYK2JAK3SYK | |
| SCHEMBL13252745 | 0.78 | SLC6A4 (0.46) | JAK2JAK1TYK2JAK3CDK4 | |
| SCHEMBL12120874 | 0.78 | CDK1 (0.60) | JAK2JAK1TYK2JAK3CDK4 | |
| SCHEMBL13574016 | 0.78 | JAK2 (0.48) | JAK2JAK1TYK2JAK3SYK | |
| SCHEMBL17529315 | 0.77 | IKBKB (0.43) | JAK2JAK1TYK2JAK3IKBKB | |
| SCHEMBL1634976 | 0.77 | JAK2 (0.60) | JAK2JAK1TYK2JAK3SYK | |
| SCHEMBL13252148 | 0.76 | CDK2 (0.45) | JAK2JAK1TYK2JAK3SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321299-B1 | PYRIDONS AS PDK1 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2016-02-24 | — | — | EP | disclosed |