Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 6/20 | 0.48 |
| ▸ | CHUK | O15111 | 4/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 3/20 | 0.44 |
| ▸ | CDK2 | P24941 | 3/20 | 0.44 |
| ▸ | CDK9 | P50750 | 3/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.44 |
| ▸ | CDK7 | P50613 | 2/20 | 0.44 |
| ▸ | CCNH | P51946 | 2/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 5/20 | 0.41 |
| ▸ | STK4 | Q13043 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12764372 | 0.89 | IKBKB (0.48) | IKBKBCHUKAKT1ROCK1JAK2 | |
| SCHEMBL17529314 | 0.86 | JAK2 (0.55) | IKBKBCHUKROCK1JAK2JAK1 | |
| SCHEMBL1633545 | 0.85 | JAK2 (0.65) | IKBKBCHUKAKT1ROCK1JAK2 | |
| SCHEMBL1633346 | 0.85 | CDK2 (0.43) | IKBKBJAK2JAK1TYK2JAK3 | |
| SCHEMBL1632091 | 0.84 | IKBKB (0.47) | IKBKBCHUKAKT1ROCK1JAK2 | |
| SCHEMBL1633008 | 0.83 | CDK1 (0.46) | IKBKBCHUKAKT1ROCK1JAK2 | |
| SCHEMBL4059017 | 0.82 | IGF1R (0.51) | IKBKBCHUKAKT1ROCK1IGF1R | |
| SCHEMBL1631095 | 0.81 | STK4 (0.45) | IKBKBIGF1RCDK1CDK2CDK9 | |
| SCHEMBL1570832 | 0.81 | CA2 (0.52) | IKBKBCDK1CDK2CDK9CCNT1 | |
| SCHEMBL1634422 | 0.80 | JAK2 (0.58) | IKBKBCHUKAKT1ROCK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |