SCHEMBL17530622

SCHEMBL17530622

CCN(c1cn2nc(-c3ccc(F)cc3)c(C(=O)NC)c2cc1-c1cccc(C(=O)N(c2ccccn2)C2CC2)c1)S(C)(=O)=O

nearest known ligand 0.44

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.39
NPC1 O15118 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17530639 0.91 ALDH1A1 (0.40) ALDH1A1NPC1
SCHEMBL17530621 0.86 ALDH1A1 (0.38) ALDH1A1NPC1
SCHEMBL2464251 0.83 CYP2C8 (0.47)
SCHEMBL2466939 0.83
SCHEMBL17530686 0.81 CYP3A4 (0.33)
SCHEMBL1935044 0.81 PPARG (0.36)
SCHEMBL1935953 0.78 CYP2C8 (0.46)
SCHEMBL3208394 0.78 ALDH1A1 (0.38) ALDH1A1NPC1
SCHEMBL1936898 0.77
SCHEMBL1936405 0.77 CYP2C9 (0.45)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2331502-B1 COMPOUNDS FOR THE TREATMENT OF HEPATITIS C BRISTOL MYERS SQUIBB CO (US) 2016-03-02 EP disclosed