SCHEMBL17530722

SCHEMBL17530722

CC(C)(C)[Si](C)(C)OCCCS(=O)(=O)Nc1cn2nc(-c3ccc(F)cc3)c(C(=O)O)c2cc1O

nearest known ligand 0.37

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BRAF P15056 11/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2988009 0.93 LMNA (0.36) BRAF
SCHEMBL1936686 0.83 BRAF (0.34) BRAF
SCHEMBL3260972 0.80
SCHEMBL2993575 0.79 LMNA (0.40) BRAF
SCHEMBL2998731 0.75 BRAF (0.46) BRAF
SCHEMBL17332223 0.74 BRAF (0.39) BRAF
SCHEMBL1935029 0.74 LMNA (0.36)
SCHEMBL2994080 0.73 BRAF (0.38) BRAF
SCHEMBL2996833 0.73 BRAF (0.35) BRAF
SCHEMBL2989353 0.73 BRAF (0.46) BRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2331502-B1 COMPOUNDS FOR THE TREATMENT OF HEPATITIS C BRISTOL MYERS SQUIBB CO (US) 2016-03-02 EP disclosed