SCHEMBL17530745

SCHEMBL17530745

[CH2]c1c(-c2cc(Nc3ccc(N4CCN(C5COC5)CC4)cn3)c(=O)n(C)c2)cc(F)cc1N1CCn2c(cc3c2CCCC3)C1=O

nearest known ligand 0.86

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BTK Q06187 20/20 0.86

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1393091 0.92 BTK (1.00) BTK
SCHEMBL2594784 0.92 BTK (0.84) BTK
SCHEMBL10256058 0.92 BTK (0.90) BTK
SCHEMBL14760391 0.91 BTK (0.75) BTK
SCHEMBL18759191 0.91 BTK (0.72) BTK
SCHEMBL1393736 0.91 BTK (0.97) BTK
SCHEMBL1392750 0.89 BTK (0.86) BTK
SCHEMBL14912250 0.86 BTK (1.00) BTK
SCHEMBL1393382 0.86 BTK (1.00) BTK
SCHEMBL31158066 0.86 BTK (1.00) BTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2566869-B1 PYRIDONE AND AZA-PYRIDONE COMPOUNDS AND METHODS OF USE GILEAD CONNECTICUT INC (US) 2016-03-02 EP claimed