SCHEMBL17533296

SCHEMBL17533296

NC(=O)NCc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O

nearest known ligand 0.67

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 19/20 0.67
DDB1 Q16531 15/20 0.67
ALDH1A1 P00352 1/20 0.56
CHRM2 P08172 1/20 0.56
OPRM1 P35372 1/20 0.56
IKZF3 Q9UKT9 1/20 0.56
CYP1A2 P05177 1/20 0.56
TSHR P16473 1/20 0.56
TDP1 Q9NUW8 1/20 0.56
GSPT1 P15170 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22685643 0.90 CRBN (0.71) CRBNDDB1ALDH1A1CHRM2OPRM1
SCHEMBL25210651 0.89 CRBN (0.68) CRBNDDB1ALDH1A1CHRM2OPRM1
SCHEMBL13578905 0.88 CRBN (0.66) CRBNDDB1ALDH1A1CHRM2OPRM1
SCHEMBL15128643 0.86 CRBN (0.66) CRBNDDB1ALDH1A1CHRM2OPRM1
SCHEMBL29439943 0.86 CRBN (0.63) CRBNDDB1ALDH1A1CHRM2OPRM1
SCHEMBL30382213 0.86 CRBN (0.81) CRBNDDB1ALDH1A1CHRM2OPRM1
SCHEMBL1413835 0.85 CRBN (0.68) CRBNDDB1ALDH1A1CHRM2OPRM1
SCHEMBL4448238 0.85 CRBN (0.62) CRBNDDB1ALDH1A1CHRM2OPRM1
SCHEMBL1413706 0.85 CRBN (0.62) CRBNDDB1ALDH1A1CHRM2OPRM1
SCHEMBL1413689 0.85 CRBN (0.75) CRBNDDB1ALDH1A1CHRM2OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116323570-B Compounds and methods for treating diseases 上海睿跃生物科技有限公司 2025-02-11 CN claimed
CN-116323570-A Compounds and methods for treating diseases 上海睿跃生物科技有限公司 2023-06-23 CN claimed
WO-2022068933-A1 COMPOUNDS AND METHODS OF TREATING DISEASES CULLGEN (SHANGHAI) , INC. (CN) 2022-04-07 WO claimed
WO-2022068933-A1 COMPOUNDS AND METHODS OF TREATING DISEASES CULLGEN (SHANGHAI) , INC. (CN) 2022-04-07 WO disclosed
WO-2016029004-A1 METHODS OF TREATING MULTIPLE MYELOMA WITH IMMUNOMODULATORY COMPOUNDS IN COMBINATION WITH ANTIBODIES CELGENE CORPORATION (US) 2016-02-25 WO disclosed