Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.71 |
| ▸ | DDB1 | Q16531 | 15/20 | 0.71 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.57 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20496821 | 0.94 | CRBN (0.63) | CRBNDDB1GSPT1ALDH1A1CHRM2 | |
| SCHEMBL17533296 | 0.90 | CRBN (0.67) | CRBNDDB1GSPT1ALDH1A1CHRM2 | |
| SCHEMBL25210651 | 0.90 | CRBN (0.68) | CRBNDDB1GSPT1ALDH1A1CHRM2 | |
| SCHEMBL30382213 | 0.89 | CRBN (0.81) | CRBNDDB1GSPT1ALDH1A1CHRM2 | |
| SCHEMBL13578905 | 0.89 | CRBN (0.66) | CRBNDDB1GSPT1ALDH1A1CHRM2 | |
| SCHEMBL1413835 | 0.89 | CRBN (0.68) | CRBNDDB1GSPT1ALDH1A1CHRM2 | |
| SCHEMBL1413689 | 0.88 | CRBN (0.75) | CRBNDDB1GSPT1ALDH1A1CHRM2 | |
| SCHEMBL29439943 | 0.87 | CRBN (0.63) | CRBNDDB1GSPT1ALDH1A1CHRM2 | |
| SCHEMBL1413642 | 0.87 | CRBN (0.64) | CRBNDDB1GSPT1ALDH1A1CHRM2 | |
| SCHEMBL31264434 | 0.87 | CRBN (0.68) | CRBNDDB1GSPT1ALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240050428-A1 | COMPOUNDS AND METHODS OF TREATING CANCERS | CULLGEN (SHANGHAI), INC. (CN) | 2024-02-15 | — | — | US | disclosed |
| WO-2023069720-A1 | COMPOUNDS THAT MEDIATE PROTEIN DEGRADATION AND METHODS OF USE THEREOF | MONTE ROSA THERAPEUTICS, INC. (US) | 2023-04-27 | — | — | WO | disclosed |
| US-11345712-B2 | Protein-targeting compounds and pharmaceutical compositions thereof, and their therapeutic applications | BIOTHERYX, INC. (US) | 2022-05-31 | — | — | US | disclosed |
| US-20210145812-A1 | AMINOAMIDE COMPOUNDS | BIOTHERYX, INC. (US) | 2021-05-20 | — | — | US | disclosed |
| US-10905684-B2 | Aminoamide compounds | BIOTHERYX, INC. (US) | 2021-02-02 | — | — | US | disclosed |
| WO-2020242960-A1 | COMPOUNDS TARGETING PROTEINS AND PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2020-12-03 | — | — | WO | disclosed |
| US-20200369679-A1 | PROTEIN-TARGETING COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. | 2020-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10905684-B2 | Aminoamide compounds | DNPEP, BCAT2, AADAT | CRBN 2355/4885DDB1 1072/4885GSPT1 662/4885 |
| US-20240050428-A1 | COMPOUNDS AND METHODS OF TREATING CANCERS | GSPT1, GGT1, VHL | CRBN 1484/4885DDB1 530/4885GSPT1 1/4885 |
| US-11345712-B2 | Protein-targeting compounds and pharmaceutical compositions thereof, and their therapeutic applications | HSP90B1, EIF4EBP1, SERPINA6 | CRBN 358/4885DDB1 834/4885GSPT1 428/4885 |
| US-20200369679-A1 | PROTEIN-TARGETING COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | HSP90B1, EIF4EBP1, SERPINA6 | CRBN 358/4885DDB1 834/4885GSPT1 428/4885 |
| US-20210145812-A1 | AMINOAMIDE COMPOUNDS | DNPEP, BCAT2, AADAT | CRBN 2355/4885DDB1 1072/4885GSPT1 662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.