Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 12/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA3 | P07451 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1753451 | 0.87 | PTGDR2 (0.66) | PTGDR2TSHRHTR2AHTR2CHTR2B | |
| SCHEMBL1753613 | 0.86 | TSHR (0.52) | PTGDR2TSHRHTR2AHTR2CHTR2B | |
| SCHEMBL1753418 | 0.85 | PTGDR2 (0.76) | PTGDR2TSHRHTR2AHTR2CHTR2B | |
| SCHEMBL1690221 | 0.84 | PTGDR2 (0.57) | PTGDR2TSHRHTR2AHTR2CHTR2B | |
| SCHEMBL1690289 | 0.76 | PTGDR2 (0.60) | PTGDR2TSHRHTR2AHTR2CHTR2B | |
| SCHEMBL1753702 | 0.76 | PTGDR2 (0.54) | PTGDR2TSHRHTR2AHTR2CHTR2B | |
| SCHEMBL1690326 | 0.76 | TSHR (0.57) | PTGDR2TSHRHTR2AHTR2CHTR2B | |
| SCHEMBL1753803 | 0.74 | PTGDR2 (0.81) | PTGDR2 | |
| SCHEMBL1989949 | 0.74 | PTGDR2 (0.57) | PTGDR2TSHRHTR2AHTR2CHTR2B | |
| SCHEMBL1991223 | 0.74 | PTGDR2 (0.52) | PTGDR2TSHRHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158820-B2 | Compounds | ASTRAZENECA AB (SE) | 2012-04-17 | — | — | US | disclosed |