SCHEMBL17536643

SCHEMBL17536643

C[SiH](C)c1[c]cccn1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1429 0.67
SCHEMBL751581 0.66 HDAC8 (0.33)
SCHEMBL1671362 0.65 CYP2A6 (0.30)
Hydrochloric Acid SCHEMBL7713690 0.65
SCHEMBL1097763 0.62
SCHEMBL933811 0.62
SCHEMBL456153 0.62
SCHEMBL2035085 0.62
SCHEMBL126131 0.62
SCHEMBL2254085 0.62

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3189063-B1 BASE-CATALYZED SILYLATION OF TERMINIAL ALKYNE C-H BONDS CALIFORNIA INST OF TECHN (US) 2019-08-14 EP disclosed
US-10072030-B2 Base-catalyzed silylation of terminal alkyne C—H bonds CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2018-09-11 US disclosed
EP-3189063-A1 BASE-CATALYZED SILYLATION OF TERMINIAL ALKYNE C-H BONDS California Institute of Technology (US) 2017-07-12 EP disclosed
US-20170088563-A1 BASE-CATALYZED SILYLATION OF TERMINAL ALKYNE C-H BONDS NATIONAL SCIENCE FOUNDATION 2017-03-30 US disclosed
US-9556206-B2 Base-catalyzed silylation of terminal alkyne C—H bonds CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2017-01-31 US disclosed
WO-2016036685-A1 BASE-CATALYZED SILYLATION OF TERMINIAL ALKYNE C-H BONDS CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2016-03-10 WO disclosed
US-20160060278-A1 BASE-CATALYZED SILYLATION OF TERMINAL ALKYNE C-H BONDS CALIFORNIA INSTITUTE OF TECHNOLOGY 2016-03-03 US disclosed