SCHEMBL126131

SCHEMBL126131

COc1[c]cccn1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8129794 0.78 CLK4 (0.47)
SCHEMBL128768 0.77
SCHEMBL316092 0.77 KDM1A (0.36)
SCHEMBL15009772 0.76
SCHEMBL127036 0.76 MEN1 (0.31)
SCHEMBL16969452 0.76 RIPK1 (0.30)
SCHEMBL126770 0.74 NPC1 (0.39)
SCHEMBL2574560 0.73
SCHEMBL128601 0.73 CYP2D6 (0.41)
SCHEMBL12471591 0.73 KDM4E (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1593 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118307569-A 2-Aryl-4-boron heterocyclic compound, and stereoselective preparation method and application thereof 武汉大学 2024-07-09 CN claimed
US-20240174588-A1 METHOD FOR PREPARING CHIRAL ALKYL COMPOUNDS BY ASYMMETRIC HYDROGENATION OF OLEFINS CATALYZED BY IRON COMPLEX ZHEJIANG UNIVERSITY (CN) 2024-05-30 US claimed
EP-4373825-A1 NITRILE SUMO INHIBITORS AND USES THEREOF Suvalent Therapeutics, Inc. (US) 2024-05-29 EP claimed
WO-2024075696-A1 IMIDAZOPYRIDINE DERIVATIVES WITH BICYCLIC STRUCTURE 公立大学法人横浜市立大学 2024-04-11 WO claimed
CN-117836296-A Pyrazolopyridone compounds 百济神州有限公司 2024-04-05 CN claimed
CN-111542526-B Condensed imidazole derivatives substituted with tertiary hydroxyl groups as PI 3K-gamma inhibitors 因赛特公司 2024-01-09 CN claimed
US-20240002395-A1 COMPOUNDS AND THEIR USE FOR TREATING NEUROPATHIC PAIN THE JOHNS HOPKINS UNIVERSITY 2024-01-04 US claimed
EP-4284797-A1 PYRAZOLEAMIDE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2023-12-06 EP claimed
US-20230381142-A1 ANTILEISHMANIAL COMPOUNDS, COMPOSITIONS AND USE THEREOF TRUSTEES OF BOSTON UNIVERSITY (US) 2023-11-30 US claimed
US-20230382911-A1 PYRAZOLEAMIDE DERIVATIVES HOFFMANN-LA ROCHE INC. (US) 2023-11-30 US claimed
WO-2002014311-A2 UREA COMPOUNDS AND METHODS OF USES AMGEN INC. (US) 2002-02-21 WO claimed
WO-2001032625-A1 ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE AND SEROTONIN DU PONT PHARMACEUTICALS COMPANY (US) 2001-05-10 WO claimed
EP-0812832-A1 Improved process for pyrimidinone compounds ROHM AND HAAS COMPANY (US) 1997-12-17 EP claimed
US-5698576-A POSSESS ANTI-ULCER AND 5-LIPOXYGENASE INHIBITORY ACTIVITIES SANKYO COMPANY, LIMITED (JP) 1997-12-16 US claimed
EP-0697403-A1 Derivatives of glycinamides as cholecystokinin receptor agonists SANOFI (FR) 1996-02-21 EP claimed
US-5276150-A Vasodilators, anticoagulants, calcium channel blockers FUJIREBIO INC. (JP) 1994-01-04 US claimed
EP-0400660-A1 1,4-dihydropyridine derivatives FUJIREBIO INC. (JP) 1990-12-05 EP claimed
US-4269842-A Method for treating rhinoviral complaints RHONE-POULENC INDUSTRIES (FR) 1981-05-26 US claimed
US-3961065-A HYPOGLYCEMIC AGENTS PFIZER INC. (US) 1976-06-01 US claimed
US-3944524-A ORAL HYPOGLYCEMIC AGENTS PFIZER INC. (US) 1976-03-16 US claimed