Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.68 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.68 |
| ▸ | FBP1 | P09467 | 2/20 | 0.60 |
| ▸ | KDR | P35968 | 2/20 | 0.57 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.55 |
| ▸ | DUS2 | Q9NX74 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | INSR | P06213 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | FLT4 | P35916 | 1/20 | 0.55 |
| ▸ | CLK1 | P49759 | 1/20 | 0.55 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.55 |
| ▸ | TEK | Q02763 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19026695 | 0.86 | EGFR (0.69) | EGFRERBB2FBP1KDRERBB3 | |
| SCHEMBL19026693 | 0.85 | EGFR (0.74) | EGFRERBB2FBP1KDRAURKA | |
| SCHEMBL17538496 | 0.85 | EGFR (0.86) | EGFRERBB2KDRERBB3DUS2 | |
| SCHEMBL19026904 | 0.85 | EGFR (0.67) | EGFRERBB2FBP1KDRERBB3 | |
| SCHEMBL18979196 | 0.85 | EGFR (0.69) | EGFRERBB2FBP1KDRERBB3 | |
| SCHEMBL17538488 | 0.82 | EGFR (0.81) | EGFRERBB2FBP1KDR | |
| SCHEMBL17538494 | 0.82 | FBP1 (0.70) | EGFRERBB2FBP1KDRAURKA | |
| SCHEMBL17538484 | 0.81 | EGFR (0.76) | EGFRERBB2FBP1KDRERBB3 | |
| SCHEMBL17538543 | 0.81 | EGFR (0.76) | EGFRERBB2FBP1KDRERBB3 | |
| SCHEMBL17538497 | 0.81 | EGFR (0.76) | EGFRERBB2FBP1KDRERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016023217-A1 | QUINAZOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | 安润医药科技（苏州）有限公司 | 2016-02-18 | — | — | WO | disclosed |