Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRL | P40313 | 2/20 | 0.32 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.32 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.32 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.32 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.32 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.32 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.32 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.32 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.32 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.32 |
| ▸ | PSMA5 | P28066 | 2/20 | 0.32 |
| ▸ | PSMB4 | P28070 | 2/20 | 0.32 |
| ▸ | PSMB6 | P28072 | 2/20 | 0.32 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.32 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.32 |
| ▸ | PSMB3 | P49720 | 2/20 | 0.32 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.32 |
| ▸ | PSMA6 | P60900 | 2/20 | 0.32 |
| ▸ | PSMA8 | Q8TAA3 | 2/20 | 0.32 |
| ▸ | PSMB7 | Q99436 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17539147 | 0.93 | PYGL (0.32) | PYGLNPC1TP53HPGDTSHR | |
| SCHEMBL17532348 | 0.92 | F2 (0.32) | PYGLNPC1TP53HPGDTSHR | |
| SCHEMBL22167427 | 0.91 | PYGL (0.31) | PYGLNPC1TP53HPGDTSHR | |
| SCHEMBL17492904 | 0.91 | PYGL (0.31) | PYGLNPC1TP53HPGDTSHR | |
| SCHEMBL17492905 | 0.91 | PYGL (0.31) | PYGLNPC1TP53HPGDTSHR | |
| SCHEMBL17532347 | 0.90 | PYGL (0.31) | PYGL | |
| SCHEMBL17539201 | 0.87 | S1PR1 (0.33) | PSMB10PSMB2PYGLITGA4ITGB7 | |
| SCHEMBL22167409 | 0.87 | S1PR1 (0.33) | PSMB10PSMB2PYGLITGA4ITGB7 | |
| SCHEMBL22167394 | 0.86 | S1PR1 (0.34) | PSMB10PSMB2PYGLITGA4ITGB7 | |
| SCHEMBL17532297 | 0.86 | S1PR1 (0.34) | PSMB10PSMB2PYGLITGA4ITGB7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3172199-B1 | PYRIMIDINE DERIVATIVES AS GLP-1 RECEPTOR MODULATORS | CELGENE INT II SARL (CH) | 2020-07-01 | — | — | EP | disclosed |
| US-9839664-B2 | GLP-1 receptor modulators | CELGENE INTERNATIONAL II SÀRL (CH) | 2017-12-12 | — | — | US | disclosed |
| US-20170216392-A1 | NOVEL GLP-1 RECEPTOR MODULATORS | RECEPTOS LLC | 2017-08-03 | — | — | US | disclosed |
| US-9474755-B2 | GLP-1 receptor modulators | CELGENE INTERNATIONAL II SARL (CH) | 2016-10-25 | — | — | US | disclosed |
| US-20160038487-A1 | NOVEL GLP-1 RECEPTOR MODULATORS | RECEPTOS LLC | 2016-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170216392-A1 | NOVEL GLP-1 RECEPTOR MODULATORS | GLP1R, GIPR, NPY1R | CTRL 419/4885PSMB11 1265/4885PSMA7 1735/4885 |
| US-20160038487-A1 | NOVEL GLP-1 RECEPTOR MODULATORS | GLP1R, GIPR, NPY1R | CTRL 419/4885PSMB11 1265/4885PSMA7 1735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.