Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | FGF2 | P09038 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17539501 | 0.77 | FGFR1 (0.51) | FGFR1FGF2FGFR4FGFR3 | |
| SCHEMBL17539645 | 0.77 | FGFR1 (0.46) | GRM5FGFR1FGF2FGFR4FGFR3 | |
| SCHEMBL17539619 | 0.77 | FGFR1 (0.37) | FGFR1FGF2FGFR4FGFR3 | |
| SCHEMBL5114429 | 0.75 | FGFR1 (0.36) | FGFR1KDM4EFGF2FGFR4FGFR3 | |
| SCHEMBL17539628 | 0.75 | FGFR1 (0.54) | FGFR1FGF2FGFR4FGFR3 | |
| SCHEMBL17539515 | 0.74 | FGFR1 (0.50) | FGFR1FGF2FGFR4FGFR3 | |
| SCHEMBL17539488 | 0.74 | FGFR1 (0.50) | FGFR1FGF2FGFR4FGFR3 | |
| SCHEMBL17539650 | 0.74 | FGFR1 (0.48) | FGFR1FGF2FGFR4FGFR3 | |
| SCHEMBL17539486 | 0.74 | FGFR1 (0.64) | FGFR1FGF2FGFR4FGFR3 | |
| SCHEMBL17539627 | 0.74 | FGFR1 (0.38) | FGFR1FGF2FGFR4FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016027780-A1 | 4-AMINOPYRIDINE DERIVATIVE | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 2016-02-25 | — | — | WO | disclosed |