Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.53 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17542166 | 1.00 | GBA1 (0.53) | GBA1SLC18A3SIGMAR1MEN1KMT2A | |
| SCHEMBL17542192 | 1.00 | GBA1 (0.53) | GBA1SLC18A3SIGMAR1MEN1KMT2A | |
| SCHEMBL17881901 | 0.77 | GBA1 (0.77) | GBA1SLC18A3SIGMAR1MEN1KMT2A | |
| SCHEMBL17870949 | 0.77 | GBA1 (0.77) | GBA1SLC18A3SIGMAR1MEN1KMT2A | |
| SCHEMBL31469245 | 0.77 | GBA1 (0.77) | GBA1SLC18A3SIGMAR1MEN1KMT2A | |
| SCHEMBL19471082 | 0.77 | GBA1 (0.77) | GBA1SLC18A3SIGMAR1MEN1KMT2A | |
| SCHEMBL12371293 | 0.76 | GBA1 (0.57) | GBA1SLC18A3SIGMAR1MEN1KMT2A | |
| SCHEMBL20364476 | 0.73 | GBA1 (0.53) | GBA1SLC18A3SIGMAR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9767964 | 0.71 | GBA1 (0.52) | GBA1SLC18A3SIGMAR1MEN1KMT2A | |
| SCHEMBL17103032 | 0.71 | GBA1 (0.35) | GBA1SLC18A3SIGMAR1PRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3186224-A1 | SUBSTITUTED AZETIDINE DERIVATIVES AS TAAR LIGANDS | F. Hoffmann-La Roche AG (CH) | 2017-07-05 | — | — | EP | disclosed |
| WO-2016030310-A1 | SUBSTITUTED AZETIDINE DERIVATIVES AS TAAR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-03-03 | — | — | WO | disclosed |