SCHEMBL12371293

SCHEMBL12371293

c1ccc(C2NCC3C(c4ccccc4)NCC23)cc1

nearest known ligand 0.57

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
GBA1 P04062 1/20 0.57
SLC18A3 Q16572 1/20 0.43
SIGMAR1 Q99720 1/20 0.43
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.40
KDM1A O60341 1/20 0.38
MAOA P21397 1/20 0.38
PRCP P42785 1/20 0.38
TSHR P16473 1/20 0.37
CHRNA7 P36544 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2030993 0.79 GBA1 (0.47) GBA1SLC18A3SIGMAR1MEN1KMT2A
SCHEMBL28524489 0.78 GBA1 (0.46) GBA1SLC18A3SIGMAR1MEN1KMT2A
SCHEMBL31374602 0.78 GBA1 (0.46) GBA1SLC18A3SIGMAR1MEN1KMT2A
SCHEMBL17542166 0.76 GBA1 (0.53) GBA1SLC18A3SIGMAR1MEN1KMT2A
SCHEMBL17542192 0.76 GBA1 (0.53) GBA1SLC18A3SIGMAR1MEN1KMT2A
SCHEMBL17870949 0.76 GBA1 (0.77) GBA1SLC18A3SIGMAR1MEN1KMT2A
SCHEMBL17881901 0.76 GBA1 (0.77) GBA1SLC18A3SIGMAR1MEN1KMT2A
SCHEMBL20364476 0.76 GBA1 (0.53) GBA1SLC18A3SIGMAR1MEN1KMT2A
SCHEMBL31469245 0.76 GBA1 (0.77) GBA1SLC18A3SIGMAR1MEN1KMT2A
SCHEMBL19471082 0.76 GBA1 (0.77) GBA1SLC18A3SIGMAR1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110202328-A1 System for the determination of selective absorbent molecules through predictive correlations EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) 2011-08-18 US disclosed
US-20110202328-A1 System for the determination of selective absorbent molecules through predictive correlations EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) 2011-08-18 US disclosed