Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.36 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.34 |
| ▸ | TSSK1B | Q9BXA7 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GHSR | Q92847 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17549909 | 0.93 | EHMT2 (0.41) | EHMT2EHMT1HDAC1HDAC8HDAC6 | |
| SCHEMBL17544863 | 0.86 | HDAC1 (0.34) | EHMT2EHMT1HDAC1HDAC8HDAC6 | |
| SCHEMBL17545015 | 0.86 | EHMT2 (0.40) | EHMT2CACNA2D1PLA2G2A | |
| SCHEMBL17544811 | 0.86 | EHMT2 (0.41) | EHMT2EHMT1HDAC1HDAC8HDAC6 | |
| SCHEMBL17670429 | 0.84 | EHMT2 (0.41) | EHMT2EHMT1HDAC1HDAC8HDAC6 | |
| SCHEMBL17544728 | 0.80 | EHMT2 (0.44) | EHMT2EHMT1HDAC1HDAC8HDAC6 | |
| SCHEMBL17545158 | 0.78 | EHMT2 (0.40) | EHMT2EHMT1HDAC1HDAC8HDAC6 | |
| SCHEMBL17544550 | 0.76 | PDE6D (0.38) | SMN1; SMN2RAB9ANPSR1 | |
| SCHEMBL17670405 | 0.75 | EHMT2 (0.39) | EHMT2EHMT1HDAC1HDAC8HDAC6 | |
| SCHEMBL17670431 | 0.73 | USP2 (0.39) | EHMT2EHMT1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3186238-A1 | COMPOUNDS AND METHODS FOR INHIBITING HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. (US) | 2017-07-05 | — | — | EP | disclosed |
| WO-2016033169-A1 | COMPOUNDS AND METHODS FOR INHIBITING HISTONE DEMETHYLASES | EPITHERAPEUTICS APS (US) | 2016-03-03 | — | — | WO | disclosed |