Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.31 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.31 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17544618 | 0.86 | EHMT2 (0.36) | HDAC1HDAC8HDAC6HDAC11TACR1 | |
| SCHEMBL17549909 | 0.83 | EHMT2 (0.41) | HDAC1HDAC8HDAC6HDAC11CACNA2D1 | |
| SCHEMBL17545015 | 0.78 | EHMT2 (0.40) | CACNA2D1EHMT2POLBPLA2G2AUSP2 | |
| SCHEMBL17670429 | 0.75 | EHMT2 (0.41) | HDAC1HDAC8HDAC6HDAC11KLKB1 | |
| SCHEMBL17544811 | 0.73 | EHMT2 (0.41) | HDAC1HDAC8HDAC6HDAC11KLKB1 | |
| SCHEMBL17544728 | 0.71 | EHMT2 (0.44) | HDAC1HDAC8HDAC6HDAC11CACNA2D1 | |
| SCHEMBL17545158 | 0.68 | EHMT2 (0.40) | HDAC1HDAC8HDAC6KLKB1EHMT2 | |
| SCHEMBL17544550 | 0.66 | PDE6D (0.38) | POLBSMN1; SMN2 | |
| SCHEMBL17544666 | 0.66 | EHMT2 (0.44) | HDAC1HDAC8KLKB1EHMT2POLB | |
| SCHEMBL17670405 | 0.65 | EHMT2 (0.39) | HDAC1HDAC8HDAC6EHMT2EHMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9802941-B2 | Compounds and methods for inhibiting histone demethylases | GILEAD SCIENCES, INC. (US) | 2017-10-31 | — | — | US | disclosed |
| EP-3186238-A1 | COMPOUNDS AND METHODS FOR INHIBITING HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. (US) | 2017-07-05 | — | — | EP | disclosed |
| US-20160102096-A1 | COMPOUNDS AND METHODS FOR INHIBITING HISTONE DEMETHYLASES | EPITHERAPEUTICS APS | 2016-04-14 | — | — | US | disclosed |
| WO-2016033169-A1 | COMPOUNDS AND METHODS FOR INHIBITING HISTONE DEMETHYLASES | EPITHERAPEUTICS APS (US) | 2016-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160102096-A1 | COMPOUNDS AND METHODS FOR INHIBITING HISTONE DEMETHYLASES | PHF8, KDM3A, PHF2 | HDAC1 29/4885HDAC8 19/4885HDAC6 132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.