Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 17/20 | 0.76 |
| ▸ | ULK2 | Q8IYT8 | 5/20 | 0.76 |
| ▸ | KIT | P10721 | 3/20 | 0.64 |
| ▸ | FLT3 | P36888 | 3/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17545176 | 0.92 | ULK1 (0.88) | ULK1ULK2KITFLT3 | |
| SCHEMBL1935005 | 0.87 | ULK1 (0.61) | ULK1ULK2 | |
| SCHEMBL17544373 | 0.86 | ULK1 (1.00) | ULK1ULK2KITFLT3 | |
| SCHEMBL19661046 | 0.85 | ULK1 (0.76) | ULK1ULK2KITFLT3 | |
| SCHEMBL26506688 | 0.83 | ULK1 (0.77) | ULK1ULK2KITFLT3 | |
| SCHEMBL1430502 | 0.82 | ULK1 (0.71) | ULK1ULK2 | |
| SCHEMBL30860794 | 0.82 | ULK1 (0.67) | ULK1ULK2 | |
| SCHEMBL1916896 | 0.81 | FLT3 (0.67) | ULK1ULK2KITFLT3 | |
| SCHEMBL1917078 | 0.81 | FLT3 (0.67) | ULK1ULK2KITFLT3 | |
| SCHEMBL1916411 | 0.81 | FLT3 (0.67) | ULK1ULK2KITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3185868-A1 | NOVEL ULK1 INHIBITORS AND METHODS USING SAME | Salk Institute for Biological Studies (US) | 2017-07-05 | — | — | EP | disclosed |
| WO-2016033100-A1 | NOVEL ULK1 INHIBITORS AND METHODS USING SAME | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2016-03-03 | — | — | WO | disclosed |