Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 2/20 | 0.76 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.69 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.67 |
| ▸ | INSR | P06213 | 2/20 | 0.67 |
| ▸ | IGF1R | P08069 | 2/20 | 0.67 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.67 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.62 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.60 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.60 |
| ▸ | EGFR | P00533 | 2/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.58 |
| ▸ | CDC7 | O00311 | 1/20 | 0.58 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.58 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.58 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.58 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19639636 | 0.95 | ULK1 (0.77) | ULK1PTK2PKMYT1INSRIGF1R | |
| SCHEMBL17547489 | 0.86 | ULK1 (1.00) | ULK1PTK2PKMYT1INSRIGF1R | |
| SCHEMBL19654233 | 0.84 | ULK1 (0.82) | ULK1PTK2PKMYT1INSRIGF1R | |
| SCHEMBL19639608 | 0.83 | ULK1 (0.81) | ULK1PTK2PKMYT1INSRIGF1R | |
| SCHEMBL17547516 | 0.82 | PTK2 (1.00) | ULK1PTK2PKMYT1INSRIGF1R | |
| SCHEMBL31174582 | 0.81 | PTK2 (0.68) | ULK1PTK2PKMYT1INSRIGF1R | |
| SCHEMBL19639648 | 0.81 | SYK (0.51) | ULK1PKMYT1FGFR1JAK2CDK2 | |
| SCHEMBL31174594 | 0.80 | PTK2 (0.69) | ULK1PTK2PKMYT1INSRIGF1R | |
| SCHEMBL2035845 | 0.79 | ULK1 (0.60) | ULK1PTK2PTK2BMAPK9MAPK10 | |
| SCHEMBL23764766 | 0.77 | MAPK9 (0.66) | ULK1PTK2PKMYT1INSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3185868-A1 | NOVEL ULK1 INHIBITORS AND METHODS USING SAME | Salk Institute for Biological Studies (US) | 2017-07-05 | — | — | EP | disclosed |
| WO-2016033100-A1 | NOVEL ULK1 INHIBITORS AND METHODS USING SAME | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2016-03-03 | — | — | WO | disclosed |