Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | CSF1R | P07333 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 8/20 | 0.44 |
| ▸ | JAK1 | P23458 | 5/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.40 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17545975 | 1.00 | CHEK1 (0.56) | CHEK1AURKACSF1RL3MBTL1BTK | |
| SCHEMBL17545876 | 0.92 | CHEK1 (0.54) | CHEK1AURKACSF1RL3MBTL1BTK | |
| SCHEMBL17545887 | 0.92 | CHEK1 (0.54) | CHEK1AURKACSF1RL3MBTL1BTK | |
| SCHEMBL2733906 | 0.91 | CHEK1 (0.52) | CHEK1AURKACSF1RL3MBTL1BTK | |
| SCHEMBL28401502 | 0.84 | JAK3 (0.52) | CHEK1AURKACSF1RL3MBTL1BTK | |
| SCHEMBL14347072 | 0.82 | JAK3 (0.63) | CHEK1AURKACSF1RL3MBTL1BTK | |
| SCHEMBL20183448 | 0.79 | JAK1 (0.71) | JAK3JAK1JAK2 | |
| SCHEMBL20183439 | 0.79 | JAK1 (0.71) | JAK3JAK1JAK2 | |
| SCHEMBL20183438 | 0.79 | JAK1 (0.71) | JAK3JAK1JAK2 | |
| SCHEMBL31492342 | 0.75 | CHEK2 (0.58) | CHEK1L3MBTL1JAK3JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9273028-B2 | Heterocyclic tyrosine kinase inhibitors | BIOGEN MA INC. (US) | 2016-03-01 | — | — | US | disclosed |
| US-9273028-B2 | Heterocyclic tyrosine kinase inhibitors | BIOGEN MA INC. (US) | 2016-03-01 | — | — | US | disclosed |