Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 11/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17545975 | 0.84 | CHEK1 (0.56) | JAK3CHEK1AURKACSF1RL3MBTL1 | |
| SCHEMBL17545980 | 0.84 | CHEK1 (0.56) | JAK3CHEK1AURKACSF1RL3MBTL1 | |
| SCHEMBL18134011 | 0.81 | JAK3 (0.72) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL28412373 | 0.81 | JAK3 (0.72) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL29216398 | 0.81 | JAK3 (0.72) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL11949307 | 0.81 | JAK3 (0.72) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL1120755 | 0.81 | JAK3 (0.72) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL19757378 | 0.81 | JAK3 (0.72) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL18124371 | 0.81 | JAK3 (0.72) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL29678116 | 0.81 | JAK3 (0.72) | JAK3JAK1JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105732637-B | Heteroaromatic compounds and their use in medicine | 广东东阳光药业有限公司 | 2020-04-21 | — | — | CN | disclosed |