Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4562407 | 0.82 | GRM2 (0.50) | GRM2 | |
| SCHEMBL740953 | 0.79 | GRM2 (0.45) | GRM2 | |
| SCHEMBL10819349 | 0.76 | GRM2 (0.44) | GRM2 | |
| SCHEMBL4562272 | 0.72 | GRM2 (0.48) | GRM2 | |
| SCHEMBL741619 | 0.69 | GRM2 (0.42) | GRM2 | |
| SCHEMBL21745150 | 0.69 | CA12 (0.41) | — | |
| SCHEMBL21713326 | 0.69 | CYP1A2 (0.45) | — | |
| SCHEMBL21713652 | 0.69 | KCNJ1 (0.31) | — | |
| SCHEMBL21714210 | 0.68 | HSD11B1 (0.40) | — | |
| SCHEMBL21713998 | 0.67 | SMN1; SMN2 (0.35) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9271967-B2 | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors | Janssen Pharmaceuticals, Inc. (US) | 2016-03-01 | — | — | US | disclosed |