Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.81 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | MC5R | P33032 | 1/20 | 0.37 |
| ▸ | MC3R | P41968 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12414488 | 0.90 | FAAH (0.81) | FAAHCES2CSNK2A2CSNK2A1 | |
| SCHEMBL2183327 | 0.90 | FAAH (1.00) | FAAHTRPV1MGLLCES2KDM4E | |
| SCHEMBL13705789 | 0.83 | FAAH (0.71) | FAAHTRPV1MGLLCES2KDM4E | |
| SCHEMBL2184819 | 0.83 | FAAH (0.70) | FAAHTRPV1MGLLCES2 | |
| SCHEMBL526735 | 0.82 | FAAH (0.65) | FAAHCES2KDM4EAOC3GRIN2B | |
| SCHEMBL2181000 | 0.79 | FAAH (0.64) | FAAHCES2 | |
| SCHEMBL19312030 | 0.78 | FAAH (0.64) | FAAHCES2CSNK2A2CSNK2A1 | |
| SCHEMBL25081015 | 0.78 | FAAH (0.63) | FAAHTRPV1MGLL | |
| SCHEMBL25080940 | 0.77 | FAAH (0.62) | FAAHKDM4E | |
| SCHEMBL425371 | 0.75 | FAAH (0.60) | FAAHCES2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160139162-A1 | Inhibitors Of Fatty Acid Amide Hydrolase And Monoacylglycerol Lipase For Modulation Of Cannabinoid Receptors | NORTHEASTERN UNIVERSITY | 2016-05-19 | — | — | US | disclosed |
| US-9271962-B2 | Inhibitors of fatty acid amide hydrolase and monoacylglycerol lipase for modulation of cannabinoid receptors | NORTHEASTERN UNIVERSITY (US) | 2016-03-01 | — | — | US | disclosed |