Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 19/20 | 0.56 |
| ▸ | NR1H3 | Q13133 | 14/20 | 0.55 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1754489 | 0.94 | NR1H2 (0.56) | NR1H2NR1H3RXRARXRBRXRG | |
| SCHEMBL1754655 | 0.85 | NR1H2 (0.59) | NR1H2NR1H3 | |
| SCHEMBL1754023 | 0.84 | NR1H2 (0.59) | NR1H2NR1H3 | |
| SCHEMBL13576036 | 0.81 | RXRA (0.39) | RXRARXRBRXRG | |
| SCHEMBL1754700 | 0.80 | NR1H2 (0.59) | NR1H2NR1H3 | |
| SCHEMBL1754689 | 0.80 | NR1H2 (0.59) | NR1H2NR1H3 | |
| SCHEMBL1754638 | 0.80 | NR1H2 (0.65) | NR1H2NR1H3 | |
| SCHEMBL1754344 | 0.79 | NR1H2 (0.59) | NR1H2NR1H3RXRA | |
| SCHEMBL1754027 | 0.79 | NR1H2 (0.78) | NR1H2NR1H3 | |
| SCHEMBL1754682 | 0.79 | NR1H2 (0.67) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158662-B2 | Compounds and compositions as LXR modulators | HAMILTON (BM) | 2012-04-17 | — | — | US | disclosed |