Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 18/20 | 0.53 |
| ▸ | NR1H3 | Q13133 | 14/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1754098 | 0.93 | NR1H2 (0.52) | NR1H2NR1H3 | |
| SCHEMBL1754636 | 0.90 | NR1H2 (0.54) | NR1H2NR1H3 | |
| SCHEMBL1754199 | 0.90 | NR1H2 (0.54) | NR1H2NR1H3 | |
| SCHEMBL1754614 | 0.85 | NR1H2 (0.57) | NR1H2NR1H3PTGS2 | |
| SCHEMBL1754671 | 0.85 | NR1H2 (0.63) | NR1H2NR1H3PTGS2 | |
| SCHEMBL1754653 | 0.85 | NR1H2 (0.55) | NR1H2NR1H3 | |
| SCHEMBL1754637 | 0.85 | NR1H2 (0.57) | NR1H2NR1H3 | |
| SCHEMBL1754459 | 0.85 | NR1H2 (0.57) | NR1H2NR1H3 | |
| SCHEMBL1754346 | 0.85 | NR1H2 (0.55) | NR1H2NR1H3 | |
| SCHEMBL1754026 | 0.85 | NR1H2 (0.56) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158662-B2 | Compounds and compositions as LXR modulators | HAMILTON (BM) | 2012-04-17 | — | — | US | disclosed |