Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 6/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 3/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.35 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1707273 | 0.91 | NSD2 (0.39) | NSD2EGFRUSP2CYP1A2CLK4 | |
| SCHEMBL1706781 | 0.91 | NSD2 (0.47) | NSD2EGFRMAPK1IRAK4HTT | |
| SCHEMBL1755282 | 0.88 | EGFR (0.36) | EGFRLMNAMAPK1ERBB2ERBB4 | |
| SCHEMBL1708497 | 0.88 | NSD2 (0.49) | NSD2EGFRUSP2CYP1A2CLK4 | |
| SCHEMBL1706605 | 0.88 | NSD2 (0.40) | NSD2EGFRUSP2CYP1A2CLK4 | |
| SCHEMBL13536785 | 0.86 | NSD2 (0.45) | NSD2EGFRUSP2CYP1A2CLK4 | |
| SCHEMBL13784501 | 0.85 | MAPK1 (0.37) | EGFRLMNAMAPK1ERBB2ERBB4 | |
| SCHEMBL1755318 | 0.84 | KDR (0.37) | EGFRLMNAMAPK1ERBB2ERBB4 | |
| SCHEMBL1707495 | 0.84 | NSD2 (0.47) | NSD2EGFRMAPK1IRAK4HTT | |
| SCHEMBL1706486 | 0.80 | NSD2 (0.49) | NSD2EGFRUSP2CYP1A2CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247579-B1 | SULPHOXIMINE-SUBSTITUTED QUINAZOLINE DERIVATIVES AS IMMUNOMODULATORS, THEIR PREPARATION AND USE AS MEDICAMENTS | Bayer Pharma AG (DE) | 2012-04-18 | — | — | EP | disclosed |